Citation: Yue Li, Nong Lu, Qitian Lin, Haobing Wang, Zhuoming Liang, Yujuan Lu, Pingyu Zhang. Sono-ReCORMs for synergetic sonodynamic-gas therapy of hypoxic tumor[J]. Chinese Chemical Letters, ;2023, 34(1): 107653. doi: 10.1016/j.cclet.2022.06.076 shu

Sono-ReCORMs for synergetic sonodynamic-gas therapy of hypoxic tumor

Yue Li ^a ,
Nong Lu ^a ,
Qitian Lin ^b ,
Haobing Wang ^a ,
Zhuoming Liang ^b ,
Yujuan Lu ^{a, *,} ,
Pingyu Zhang ^{a, *,}

a.
College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China
b.
Whittle School and Studios Shenzhen Campus, Shenzhen 518066, China

yjlv@szu.edu.cn

p.zhang6@szu.edu.cn

Received Date: 11 February 2022
Revised Date: 26 June 2022
Accepted Date: 28 June 2022
Available Online: 30 June 2022

Figures(6)

Carbon monoxide (CO) gas therapy, a novel anti-tumor technique based on the cytotoxicity from the CO released in situ, has become one of the hot topics in cancer treatment. Since the technique is oxygen-independent, it displays promising therapeutic effect for hypoxic tumor where traditional photodynamic therapy shows limited efficacy and insufficient penetration depth. To fully address these limitations of PDT, we propose a synergetic sonodynamic-CO gas releasing strategy for the therapy of hypoxic tumor. In this work, two rhenium(I) tricarbonyl complexes with different substituted ligands are investigated for US-triggered ROS generation and CO release. Our results indicated that the electron-donating NMe₂-substituted complex (Re-NMe₂) exhibits stronger luminescence intensity and generates more singlet oxygen (¹O₂) than the electron-withdrawing NO₂-substituted complex (Re-NO₂). In addition, Re-NMe₂ displays release of CO triggered by US, thus showing high sono-cytotoxicity to tumor cells in-vitro and in-vivo. The strong ROS-generating capability combined with rapid CO-releasing feature from Re-NMe₂ has made it a powerful tool for the efficient treatment of hypoxic tumor.
- Synergetic sonodynamic-gas therapy,
- Carbon monoxide (CO),
- Rhenium(I) tricarbonyl complex,
- Hypoxic tumor
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