Citation: Huimin Zhu, Jingwen Yu, Jinfa Ye, Yiming Wu, Jintao Pan, Yingying Li, Chuan Chen, Li Zheng, Gang Liu, Chengchao Chu. Nanoparticle-mediated corneal neovascularization treatments: Toward new generation of drug delivery systems[J]. Chinese Chemical Letters, ;2023, 34(3): 107648. doi: 10.1016/j.cclet.2022.06.071 shu

Nanoparticle-mediated corneal neovascularization treatments: Toward new generation of drug delivery systems

Huimin Zhu ^{a, b, 1} ,
Jingwen Yu ^{b, 1} ,
Jinfa Ye ^{b, c, 1} ,
Yiming Wu ^b ,
Jintao Pan ^c ,
Yingying Li ^d ,
Chuan Chen ^d ,
Li Zheng ^{a, *,} ,
Gang Liu ^{a, c, e, *,} ,
Chengchao Chu ^{b, e, *,}

a.
Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China
b.
Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen University, Xiamen 361102, China
c.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen, Xiamen University, Xiamen 361102, China
d.
Department of Pharmacy, Xiamen Medical College, Xiamen 361023, China
e.
Shenzhen Research Institute of Xiamen University, Shenzhen 518057, China

zhengli@gxmu.edu.cn

gangliu.cmitm@xmu.edu.cn

chuchengchao@xmu.edu.cn

Received Date: 7 March 2022
Revised Date: 25 June 2022
Accepted Date: 27 June 2022
Available Online: 1 July 2022

Figures(9)

Corneal neovascularization (CNV) is one of the major factors for vision impairment and blindness worldwide. The current treatment for CNV focuses primarily on topical eyedrops of glucocorticoids, non-steroidal anti-inflammatory drugs, electro-coagulation and laser photo-coagulation. Unfortunately, coagulation-based treatment is restricted by corneal hemorrhage and iris atrophy. And drug treatments have limited therapeutic effects and a short duration of action. Nanoparticle-based drug delivery systems are widely applied due to their improved pharmacokinetics, optimized drug targeting and enhanced biocompatibility. In this article, we provide a comprehensive and systematic overview of the CNV nanodrug system, highlighting some of the recent advances in nanodrug design, preparation, and functional modification. Moreover, we discuss the challenges in the clinical translation and potential risks in CNV treatment. A greater effort is needed for the potential applications of nanotechnology in the field of ophthalmology.
- Corneal neovascularization,
- Nanoparticles,
- Drug delivery system,
- Anti-VEGF,
- Supramolecular assembly
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沈阳化工大学材料科学与工程学院沈阳 110142