Citation: Yaohang Cheng, Xian Zhang, Guanghui An, Guangming Li, Zhenyu Yang. Visible-light-enabled ruthenium-catalyzed para-C−H difluoroalkylation of anilides[J]. Chinese Chemical Letters, ;2023, 34(3): 107625. doi: 10.1016/j.cclet.2022.06.048 shu

Visible-light-enabled ruthenium-catalyzed para-C−H difluoroalkylation of anilides

a.
Key Laboratory of Functional Inorganic Material Chemistry (MOE), School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, China
b.
School of Pharmaceutical and Materials Engineering, Taizhou University, Taizhou 318000, China

chemagh@163.com

Received Date: 14 April 2022
Revised Date: 15 June 2022
Accepted Date: 19 June 2022
Available Online: 23 June 2022

Figures(6)

Visible-light-mediated para-C–H difluoroalkylation of anilides via combination of steric effects and Lewis acid activation strategies has been developed. The addition of (C₆H₅O)₂P(O)OH and Ag₂CO₃ properly tune the redox potential of ruthenium catalyst and leads to mild reaction conditions. The protocol exhibits broad functional group tolerance and allows the late-stage functionalization of complex bioactive molecules.
- C−H activation,
- para-Selectivity,
- Photocatalysis,
- Difluoroalkylation,
- Late-stage functionalization
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