Citation: Yi Liu, Man Zhu, Minsi Meng, Qiao Wang, Yun Wang, Yu Lei, Yanmin Zhang, Lin Weng, Xin Chen. A dual-responsive hyaluronic acid nanocomposite hydrogel drug delivery system for overcoming multiple drug resistance[J]. Chinese Chemical Letters, ;2023, 34(1): 107583. doi: 10.1016/j.cclet.2022.06.006 shu

A dual-responsive hyaluronic acid nanocomposite hydrogel drug delivery system for overcoming multiple drug resistance

Yi Liu ^{a, b, c, 1,*,} ,
Man Zhu ^{d, 1} ,
Minsi Meng ^{a, c, 1} ,
Qiao Wang ^{a, c} ,
Yun Wang ^a ,
Yu Lei ^a ,
Yanmin Zhang ^{d, **,} ,
Lin Weng ^{c, **,} ,
Xin Chen ^c

a.
Key Laboratories of Fine Chemicals and Surfactants in Sichuan Provincial Universities, College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong 643000, China
b.
Institute of Precision Medicine, Zigong Fourth People's Hospital, Zigong 643000, China
c.
Department of Chemical Engineering, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institution of Polymer Science in Chemical Engineering, School of Chemical Engineering and Technology, Xi'an Jiao Tong University, Xi'an 710049, China
d.
School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China

^**

yiliu@suse.edu.cn

zhang2008@xjtu.edu.cn

lwengxjtu@xjtu.edu.cn

Received Date: 7 December 2021
Revised Date: 5 June 2022
Accepted Date: 6 June 2022
Available Online: 10 June 2022

Figures(6)

Chemotherapy is restricted by efficient drug outflow due to the multiple drug resistance (MDR) in heterogenous nature of tumor. Herein, we present a dual-responsive hyaluronic acid (HA) nanocomposite hydrogel that can not only response to the tumor microenvironment but also enhance chemotherapy. This HA hydrogel consists of a core-shell SiO₂ (GOD@SiO₂-Arg) and mesoporous silica nanoparticles (MSNs) with doxorubicin (DOX) as the cargo (DOX@MSN). It could rapidly release the GOD@SiO₂-Arg nanoparticles at the low pH tumor-specific environment due to the cleavage of imine bond. GOD@SiO₂-Arg activated by over-expressed glutathione (GSH) in tumor cells releases GOD due to the cleavage of disulfide bonds, which could oxidize glucose to produce hydrogen peroxide (H₂O₂) for in situ NO generation via reaction between Arg and H₂O₂. The validity of this study might provide a method to modulate the tumor microenvironment for enhancing chemotherapy.
- Dual-responsive HA hydrogel,
- P-gp inhibition,
- MDR,
- Enhance chemotherapy
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