Citation: Fuqian Chen, Ying Zhang, Ting Li, Danfeng Peng, Zhiwen Qi, Jianping Song, Tao Deng, Fang Liu. Discovering ester and ether derivatives of luminol as advanced chemiluminescence probes[J]. Chinese Chemical Letters, ;2023, 34(3): 107496. doi: 10.1016/j.cclet.2022.05.010 shu

Discovering ester and ether derivatives of luminol as advanced chemiluminescence probes

Fuqian Chen ^a ,
Ying Zhang ^a ,
Ting Li ^a ,
Danfeng Peng ^a ,
Zhiwen Qi ^d ,
Jianping Song ^{a, c} ,
Tao Deng ^{a, c, *,} ,
Fang Liu ^{b, **,}

a.
Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
b.
School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
c.
Lingnan Medical Research Center, The first Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China
d.
Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry (CAF), Nanjing 210042, China

dengtao@gzucm.edu.cn

fangliu@gzucm.edu.cn

Received Date: 16 February 2022
Revised Date: 16 April 2022
Accepted Date: 8 May 2022
Available Online: 13 May 2022

Figures(6)

A variety of luminol derivatives with N- and O-substitution have been synthesized with broad functional group tolerance. O-esterification has been demonstrated for the first time as a promising way to prepare enhanced CL reagents for sensing hemin, bloodstain and horseradish peroxidase (HRP). The most effective analogue with a deuterated acetyl group exhibited greater potential than luminol for bloodstain imaging and HRP imaging in western blotting (WB). In addition, O-etherification can greatly suppress CL signal that has been applied to design a CL probe for β-glucosidase (β-Glu). This study offers important and useful information regarding the luminol modification and shows great potential to use O-substituted analogues for enhanced CL analysis.
- Luminol derivatives,
- Chemiluminescence (CL),
- Luminol O-modification,
- Bloodstain imaging,
- WB imaging reagent
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