Citation: Yuan He, Chang Liu, Run Han, Yingmin Liang, Judith Choi Wo Mak, Yinghao Zhu, Haifeng Li, Ying Zheng. Reducing systemic absorption and macrophages clearance of genistein by lipid-coated nanocrystals for pulmonary delivery[J]. Chinese Chemical Letters, ;2023, 34(1): 107484. doi: 10.1016/j.cclet.2022.04.082 shu

Reducing systemic absorption and macrophages clearance of genistein by lipid-coated nanocrystals for pulmonary delivery

Yuan He ^{a, b} ,
Chang Liu ^a ,
Run Han ^a ,
Yingmin Liang ^c ,
Judith Choi Wo Mak ^c ,
Yinghao Zhu ^d ,
Haifeng Li ^d ,
Ying Zheng ^{a, *,}

a.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
b.
Department of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China
c.
LKS Faculty of Medicine, Department of Medicine, The University of Hong Kong, Hong Kong, China
d.
Institute of Applied Physics and Materials Engineering, University of Macau, Macau, China

yzheng@umac.mo

Received Date: 30 November 2021
Revised Date: 27 April 2022
Accepted Date: 28 April 2022
Available Online: 2 May 2022

Figures(6)

Pulmonary delivery is an effective drug delivery strategy for the treatment of local respiratory diseases. However, the rapid systemic absorption through the lung due to the thin barrier and persistent lung clearances influence the drug retention in the lung. In this study, we designed a lipid-coated genistein nanocrystals (Lipo-NCs) formulation to achieve enhanced efficiency of local pulmonary delivery. The Lipo-NCs were fabricated by modifying genistein nanocrystals (NCs) with phospholipid membrane through thin film hydration following the homogenization method. The prepared Lipo-NCs exhibited a decreased drug release rate compared with the naked NCs. Our results demonstrated that intracellular uptake and transcellular transport of NCs by the Calu-3 epithelial layer were reduced after lipid coating. Furthermore, the macrophages clearance was also impeded by this Lipo-NCs formulation. In vivo lung retention and distribution revealed that more genistein was retained in the lung after intratracheal administration of Lipo-NCs. The pharmacokinetic study displayed that the AUC_(0-t) values of Lipo-NCs were 1.59-fold lesser than those of the NCs group, indicating a reduced systemic absorption. In conclusion, this research indicated that Lipo-NCs could be a suitable formulation for reducing systemic absorption and macrophages clearance, and thus enhancing drug concentration in lung by pulmonary delivery.
- Pulmonary delivery,
- Lipid-coated nanocrystals,
- Cell uptake,
- Transport,
- Systemic absorption,
- Macrophage clearances
1. [1]
  E.D. Bateman, S.S. Hurd, P.J. Barnes, et al., Eur. Respir. J.31 (2008) 143–178. doi: 10.1183/09031936.00138707
2. [2]
  Y. He, Y. Liang, R. Han, et al., J. Control. Release 314 (2019) 48–61. doi: 10.1016/j.jconrel.2019.10.035
3. [3]
  C.A. Ruge, J. Kirch, C.M. Lehr, Lancet Respir. Med. 1 (2013) 402–413. doi: 10.1016/S2213-2600(13)70072-9
4. [4]
  M.B. Dolovich, R. Dhand, Lancet 377 (2011) 1032–1045. doi: 10.1016/S0140-6736(10)60926-9
5. [5]
  C.N. Xu, H.Y. Tian, Y.B. Wang, et al., Chin. Chem. Lett. 28 (2017) 807–812. doi: 10.1016/j.cclet.2016.12.013
6. [6]
  J. Todoroff, R. Vanbever, Curr. Opin. Colloid Interface Sci. 16 (2011) 246–254. doi: 10.1016/j.cocis.2011.03.001
7. [7]
  Q.Y. Liu, J. Guan, L. Qin, X. Zhang, S.R. Mao, Drug Discov. Today 25 (2020) 150–159. doi: 10.1016/j.drudis.2019.09.023
8. [8]
  P.G. Rogueda, D. Traini, Expert Opin. Drug Deliv. 4 (2007) 595–606. doi: 10.1517/17425247.4.6.595
9. [9]
  J.A. Champion, A. Walker, S. Mitragotri, Pharm. Res. 25 (2008) 1815–1821. doi: 10.1007/s11095-008-9562-y
10. [10]
  B.E. Rabinow, Nat. Rev. Drug Discov. 3 (2004) 785–796. doi: 10.1038/nrd1494
11. [11]
  R.H. Muller, S. Gohla, C.M. Keck, Eur. J. Pharm. Biopharm. 78 (2011) 1–9. doi: 10.1016/j.ejpb.2011.01.007
12. [12]
  D.L. Liu, B. Wan, J.P. Qi, et al., Chin. Chem. Lett. 29 (2018) 1834–1838. doi: 10.1016/j.cclet.2018.11.015
13. [13]
  T.S. Wiedmann, L. DeCastro, R.W. Wood, Pharm. Res. 14 (1997) 112–116. doi: 10.1023/A:1012024021511
14. [14]
  C. Jacobs, R.H. Muller, Pharm. Res. 19 (2002) 189–194. doi: 10.1023/A:1014276917363
15. [15]
  T.T. Fu, Z.Q. Cong, Y. Zhao, et al., Int. J. Pharm. 572 (2019) 118839. doi: 10.1016/j.ijpharm.2019.118839
16. [16]
  Y. He, Y. Liang, J.C.W. Mak, et al., Colloids Surf. B: Biointerfaces 186 (2020) 110703. doi: 10.1016/j.colsurfb.2019.110703
17. [17]
  K. Tahara, H. Tomida, Y. Ito, et al., Int. J. Pharm. 505 (2016) 139–146. doi: 10.1016/j.ijpharm.2016.03.031
18. [18]
  A.A. Ganai, H. Farooqi, Biomed. Pharmacother. 76 (2015) 30–38. doi: 10.1016/j.biopha.2015.10.026
19. [19]
  J.W. Jung, K. Damodar, J.K. Kim, J.G. Jun, Chin. Chem. Lett. 28 (2017) 1114–1118. doi: 10.1016/j.cclet.2016.12.041
20. [20]
  J.L. Kang, H.W. Lee, H.S. Lee, et al., Am. J. Respir. Crit. Care Med. 164 (2001) 2206–2212. doi: 10.1164/ajrccm.164.12.2104017
21. [21]
  K. Kojima, K. Asai, H. Kubo, et al., Nutrients 11 (2019) 2023. doi: 10.3390/nu11092023
22. [22]
  C. de Souza Carvalho, N. Daum, C.M. Lehr, Adv. Drug Deliv. Rev. 75 (2014) 129–140. doi: 10.1016/j.addr.2014.05.014
23. [23]
  P.T. Ingvarsson, I.S. Rasmussen, M. Viaene, et al., Eur. J. Pharm. Biopharm. 87 (2014) 480–488. doi: 10.1016/j.ejpb.2014.04.001
24. [24]
  S. Hein, M. Bur, U.F. Schaefer, C.M. Lehr, Eur. J. Pharm. Biopharm. 77 (2011) 132–138. doi: 10.1016/j.ejpb.2010.10.003
25. [25]
  M.E. Kreft, U.D. Jerman, E. Lasic, et al., Eur. J. Pharm. Sci. 69 (2015) 1–9. doi: 10.1016/j.ejps.2014.12.017
26. [26]
  N. Kim, G.A. Duncan, J. Hanes, J.S. Suk, J. Control. Release 240 (2016) 465–488. doi: 10.1016/j.jconrel.2016.05.031
27. [27]
  H.S. Choi, Y. Ashitate, J.H. Lee, et al., Nat. Biotechnol. 28 (2010) 1300–1303. doi: 10.1038/nbt.1696
28. [28]
  C. Loira-Pastoriza, J. Todoroff, R. Vanbever, Adv. Drug. Deliv. Rev. 75 (2014) 81–91. doi: 10.1016/j.addr.2014.05.017
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