Citation: Mujuan Zhu, Shiping Zhu, Qiubo Liu, Yuehong Ren, Zhiguo Ma, Xingwang Zhang. Selenized liposomes with ameliorative stability that achieve sustained release of emodin but fail in bioavailability[J]. Chinese Chemical Letters, ;2023, 34(1): 107482. doi: 10.1016/j.cclet.2022.04.080 shu

Selenized liposomes with ameliorative stability that achieve sustained release of emodin but fail in bioavailability

Mujuan Zhu ^{a, 1} ,
Shiping Zhu ^{b, 1} ,
Qiubo Liu ^b ,
Yuehong Ren ^a ,
Zhiguo Ma ^{a, *,} ,
Xingwang Zhang ^{a, *,}

a.
Department of Pharmaceutics, School of Pharmacy, Jinan University, Guangzhou 511443, China
b.
Department of Chinese Traditional Medicine/Sun-Shengyun Heritage Studio of Eminent TCM Practitioner in Guangdong Province, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China

mzg1979@126.com

zhangxw@jnu.edu.cn

Received Date: 20 January 2022
Revised Date: 28 April 2022
Accepted Date: 28 April 2022
Available Online: 2 May 2022

Figures(4)

Stability of liposomes plays a crucial role in drug delivery, especially in oral aspect. The structural modification of liposomes has been the orientation of efforts to improve their stability and enable the controllability of payload release. This study reported a selenylation strategy to optimize the liposomal structure in an attempt to enhance the nanocarrier's stability, hence the bioavailability of emodin (EM), an active compound with poor water-solubility. EM-loaded selenized liposomes (EM-Se@LPs) were prepared by thin film dispersion followed by in situ reduction technique. The results showed that EM-Se@LPs were provided with enhancive gastrointestinal stability and exhibited sustained release of drug compared with EM-loaded liposomes (EM-LPs). However, the modified liposomes with Se depositing onto the interior and exterior bilayers did not substantially facilitate absorption of EM. The reinforced structure of liposomes irrelevant to absorption was affirmed to be due to good stability and absorbability of EM itself. Nevertheless, the present work provides an alternative option for stabilization of liposomes instead of conventional methods, which may be promising for oral delivery of physiologically unstable and/or poorly absorbed drugs and systemic drug delivery.
- Emodin,
- Liposomes,
- Selenium,
- Stability,
- Sustained release,
- Bioavailability
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