Citation: Yu Chong, Jiayu Ning, Shengyi Min, Jiaquan Ye, Cuicui Ge. Emerging nanozymes for potentiating radiotherapy and radiation protection[J]. Chinese Chemical Letters, ;2022, 33(7): 3315-3324. doi: 10.1016/j.cclet.2022.03.054 shu

Emerging nanozymes for potentiating radiotherapy and radiation protection

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China

chongyu@suda.edu.cn

ccge@suda.edu.cn

Received Date: 16 January 2022
Revised Date: 10 March 2022
Accepted Date: 14 March 2022
Available Online: 16 March 2022

Figures(16)

While radiotherapy is a mainstay therapeutic modality for malignant tumor, the intrinsic tumor resistance to radiotherapy, as well as the concomitant radiation injury to adjacent healthy tissues, greatly limits the efficacy of cancer radiotherapy. As a result, the development of novel radioenhancers and radioprotectants is highly desired for clinical radiotherapy. In recent years, nanozymes have inspired ever-growing research interest because of their multi-enzyme activities and microenvironment-responsive feature. In view of the significant progress of nanozymes in radiation medicine, we, in this review, systematically illustrate the impressive progress of nanozymes for potentiating radiotherapy and radiation protection. First, the types of nanozymes used in tumor radiotherapy are briefly discussed. Subsequently, the main strategies of nanozymes to enhance the radiotherapy efficiency, including promoting the generation of reactive oxygen species (ROS), relieving hypoxia in tumor microenvironment and combining with other cancer therapeutic regimens, are summarized. Finally, the advances of typical nanozymes for preventing radiation-induced hematopoietic damage and gastrointestinal damage are highlighted.
- Nanozyme,
- Radiation therapy,
- Radiosensitization,
- ROS,
- Hypoxia
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沈阳化工大学材料科学与工程学院沈阳 110142