Citation: Chun-Lan Xie, Duo Zhang, Kai-Qiang Guo, Qing-Xiang Yan, Zheng-Biao Zou, Zhi-Hui He, Zhen Wu, Xiao-Kun Zhang, Hai-Feng Chen, Xian-Wen Yang. Meroterpenthiazole A, a unique meroterpenoid from the deep-sea-derived Penicillium allii-sativi, significantly inhibited retinoid X receptor (RXR)-α transcriptional effect[J]. Chinese Chemical Letters, ;2022, 33(4): 2057-2059. doi: 10.1016/j.cclet.2021.09.073 shu

Meroterpenthiazole A, a unique meroterpenoid from the deep-sea-derived Penicillium allii-sativi, significantly inhibited retinoid X receptor (RXR)-α transcriptional effect

a.
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China
b.
School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China

yangxianwen@tio.org.cn

Received Date: 1 August 2021
Revised Date: 1 September 2021
Accepted Date: 23 September 2021
Available Online: 29 September 2021

Figures(5)

A novel meroterpenoid, named meroterpenthiazole A (1), was isolated from the deep-sea-derived Penicillium allii-sativi. Its structure was established by extensive spectroscopic and computational methods. Meroterpenthiazole A bears a rare benzothiazole moiety in nature. Compound 1 significantly inhibited retinoid X receptor (RXR)-α transcriptional effect (K_D = 12.3 µmol/L) through a novel binding mechanism.
- Deep-sea,
- Fungus,
- Penicillium allii-sativi,
- Meroterpenoids,
- Retinoid X receptor
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1.
沈阳化工大学材料科学与工程学院沈阳 110142