Citation: Sifeng Mao, Xiaohong Hu, Yumi Tanaka, Lin Zhou, Chenhan Peng, Nahoko Kasai, Hizuru Nakajima, Shungo Kato, Katsumi Uchiyama. A chemo-mechanical switchable valve on microfluidic chip based on a thermally responsive block copolymer[J]. Chinese Chemical Letters, ;2022, 33(6): 3083-3086. doi: 10.1016/j.cclet.2021.09.065 shu

A chemo-mechanical switchable valve on microfluidic chip based on a thermally responsive block copolymer

a.
Department of Applied Chemistry, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University, Hachioji-shi, Tokyo 192-0397, Japan
b.
University Education Center, Tokyo Metropolitan University, Hachioji-shi, Tokyo 192-0397, Japan

maosifeng@tmu.ac.jp

Received Date: 29 May 2021
Revised Date: 1 September 2021
Accepted Date: 20 September 2021
Available Online: 24 September 2021

Figures(4)

Microfluidic devices have become a powerful tool for chemical and biologic applications. To control different functional parts on the microchip, valve plays a key role in the device. In conventional methods, physio-mechanical valves are usually used on microfluidic chip. Herein, we reported a chemo-mechanical switchable valve on microfluidic chip by using a thermally responsive block copolymer. The wettability changes of capillary with copolymer modification on inner surface were investigated to verify the function as a valve. Capillaries with modification of poly-(N-isopropylacrylamide-co-hexafluoroisopropyl acrylate) (P(NIPAAm-co-HFIPA)) with a 20% HFIPA was demonstrated capable of control aqueous solution stop or go through. Then short capillaries with copolymer modification were integrated in microchannels as valves. With the temperature changing around lower critical solution temperature (LCST), the integrated chemo-mechanical switchable valve exhibited excellent "OPEN–CLOSE'' behavior for microflow control. After optimization of the block copolymer sequences and molar ratio, a switching time as low as 20 s was achieved. The developed micro valve was demonstrated effective for flow control on microchip.
- Microchip,
- Valve,
- Flow control,
- NIPPAm,
- Chemo-mechanical switch,
- Thermo-responsive polymer
1. [1]
  M. Jie, S. Mao, H. Li, J.-M. Lin, Chin. Chem. Lett. 28 (2017) 1625-1630. doi: 10.1016/j.cclet.2017.05.024
2. [2]
  R.R. Svejdal, D. Sticker, C. Sonderby, J.P. Kutter, K.D. Rand, Anal. Chim. Acta 1140 (2020) 168-177. doi: 10.1016/j.aca.2020.09.062
3. [3]
  Q. Wang, J. Deng, Y. Chen, Y. Luo, X. Jiang, Chin. Chem. Lett. 31 (2020) 1835-1838. doi: 10.1016/j.cclet.2020.01.028
4. [4]
  Q. Wang, J.Q. Deng, Y.P. Chen, Y.J. Luo, X.Y. Jiang, Chin. Chem. Lett. 31 (2020) 1835-1838. doi: 10.1016/j.cclet.2020.01.028
5. [5]
  K.R. Kim, H.J. Chun, K.W. Lee, et al., Lab Chip 19 (2019) 3931-3942. doi: 10.1039/C9LC00973F
6. [6]
  T.A. Meier, R.J. Beulig, E. Klinge, et al., Chem. Commun. 51 (2015) 8588-8591. doi: 10.1039/C4CC09595B
7. [7]
  S.Y. Hu, B.T. Zhang, S.W. Zeng, et al., Lab Chip 20 (2020) 3001-3010. doi: 10.1039/D0LC00202J
8. [8]
  S. Mao, W. Zhang, Q. Huang, et al., Angew. Chem. Int. Ed. 57 (2018) 236-240. doi: 10.1002/anie.201710273
9. [9]
  S. Mao, Q. Zhang, W. Liu, et al., Chem. Sci. 10 (2019) 2081-2087. doi: 10.1039/C8SC05104F
10. [10]
  T.Z. Xie, N. Li, S. Mao, Q. Zhang, J.M. Lin, ACS Omega 5 (2020) 3857-3862. doi: 10.1021/acsomega.9b03074
11. [11]
  T. Thorsen, S.J. Maerkl, S.R. Quake, Science 298 (2002) 580-584. doi: 10.1126/science.1076996
12. [12]
  B. Huang, H.K. Wu, D. Bhaya, et al., Science 315 (2007) 81-84. doi: 10.1126/science.1133992
13. [13]
  R.D. Lovchik, N. Tonna, F. Bianco, M. Matteoli, E. Delamarche, Biomed. Microdevices 12 (2010) 275-282. doi: 10.1007/s10544-009-9382-9
14. [14]
  T. Xu, W.Q. Yue, C.W. Li, et al., Lab Chip 10 (2010) 2271-2278. doi: 10.1039/c004844e
15. [15]
  A. Khademhosseini, Y.S. Zhang, Sens. Actuators B: Chem. 262 (2018) 625-636. doi: 10.1016/j.snb.2017.12.132
16. [16]
  M.A. Unger, H.P. Chou, T. Thorsen, A. Scherer, S.R. Quake, Science 288 (2000) 113-116. doi: 10.1126/science.288.5463.113
17. [17]
  S. Mao, J. Zhang, H. Li, J. -M. Lin, Anal. Chem. 85 (2013) 868-876. doi: 10.1021/ac303164b
18. [18]
  M. Tagliazucchi, O. Azzaroni, I. Szleifer, J. Am. Chem. Soc. 132 (2010) 12404-12411. doi: 10.1021/ja104152g
19. [19]
  E.K. Sackmann, A.L. Fulton, D.J. Beebe, Nature 507 (2014) 181-189. doi: 10.1038/nature13118
20. [20]
  L. Cheng, D. Cao, ACS Nano 5 (2011) 1102-1108. doi: 10.1021/nn102754g
21. [21]
  S. Demirci, N. Sahiner, Polym. Compos. 40 (2019) 3895-3903. doi: 10.1002/pc.25249
22. [22]
  S. Chaudhuri, C.M. Wu, Polymers 12 (2020) 100-114. doi: 10.3390/polym12010100
23. [23]
  C. Boztepe, M. Yüceer, A. Künkül, M. Șölener, O.S. Kabasakal, Res. Chem. Intermed. 46 (2020) 409-428. doi: 10.1007/s11164-019-03957-3
24. [24]
  C. Boztepe, M. Yuceer, A. Kunkul, M. Solener, O.S. Kabasakal, Res. Chem. Intermed. 46 (2020) 409-428. doi: 10.1007/s11164-019-03957-3
25. [25]
  T.A. Meier, R.J. Beulig, E. Klinge, M. Fuss, S. Ohla, D. Belder, Chem. Commun. 51 (2015) 8588-8591. doi: 10.1039/C4CC09595B
26. [26]
  Y. Wang, N. Yang, D.D. Wang, et al., Polym. Degrad. Stab. 147 (2018) 123-131. doi: 10.1016/j.polymdegradstab.2017.11.023
27. [27]
  R. Pelton, J. Colloid Interface Sci. 348 (2010) 673-674. doi: 10.1016/j.jcis.2010.05.034
28. [28]
  D. Qin, Y. Xia, G.M. Whitesides, Nat. Protoc. 5 (2010) 491-502. doi: 10.1038/nprot.2009.234
1. [1]
  Yong-Dan Zhao , Yidan Wang , Rongrong Wang , Lina Chen , Hengtong Zuo , Xi Wang , Jihong Qiang , Geng Wang , Qingxia Li , Canqi Ping , Shuqiu Zhang , Hao Wang . Reversing artemisinin resistance by leveraging thermo-responsive nanoplatform to downregulating GSH. Chinese Chemical Letters, 2024, 35(6): 108929-. doi: 10.1016/j.cclet.2023.108929
2. [2]
  Chun-Yun Ding , Ru-Yuan Zhang , Yu-Wu Zhong , Jiannian Yao . Binary and heterostructured microplates of iridium and ruthenium complexes: Preparation, characterization, and thermo-responsive emission. Chinese Journal of Structural Chemistry, 2024, 43(10): 100393-100393. doi: 10.1016/j.cjsc.2024.100393
3. [3]
  Xinpin Pan , Yongjian Cui , Zhe Wang , Bowen Li , Hailong Wang , Jian Hao , Feng Li , Jing Li . Robust chemo-mechanical stability of additives-free SiO₂ anode realized by honeycomb nanolattice for high performance Li-ion batteries. Chinese Chemical Letters, 2024, 35(10): 109567-. doi: 10.1016/j.cclet.2024.109567
4. [4]
  Wangyan Hu , Ke Li , Xiangnan Dou , Ning Li , Xiayan Wang . Nano-sized stationary phase packings retained by single-particle frit for microchip liquid chromatography. Chinese Chemical Letters, 2024, 35(4): 108806-. doi: 10.1016/j.cclet.2023.108806
5. [5]
  Yan Liu , Yang Wang , Jiayi Zhu , Xuxian Su , Xudong Lin , Liang Xu , Xiwen Xing . Employing pH-responsive RNA triplex to control CRISPR/Cas9-mediated gene manipulation in mammalian cells. Chinese Chemical Letters, 2024, 35(9): 109427-. doi: 10.1016/j.cclet.2023.109427
6. [6]
  Pei Cao , Yilan Wang , Lejian Yu , Miao Wang , Liming Zhao , Xu Hou . Dynamic asymmetric mechanical responsive carbon nanotube fiber for ionic logic gate. Chinese Chemical Letters, 2024, 35(6): 109421-. doi: 10.1016/j.cclet.2023.109421
7. [7]
  Zhongjie Li , Xiangyue Kong , Yuhao Liu , Huayu Qiu , Lingling Zhan , Shouchun Yin . Progress of additives for morphology control in organic photovoltaics. Chinese Chemical Letters, 2024, 35(6): 109378-. doi: 10.1016/j.cclet.2023.109378
8. [8]
  Hui Jin , Qin Cai , Peiwen Liu , Yan Chen , Derong Wang , Weiping Zhu , Yufang Xu , Xuhong Qian . Multistep continuous flow synthesis of Erlotinib. Chinese Chemical Letters, 2024, 35(4): 108721-. doi: 10.1016/j.cclet.2023.108721
9. [9]
  Huangjie Lu , Yingzhe Du , Peng Lin , Jian Lin . Separation of americium from lanthanides based on oxidation state control. Chinese Journal of Structural Chemistry, 2024, 43(10): 100344-100344. doi: 10.1016/j.cjsc.2024.100344
10. [10]
  Peiwen Liu , Fang Zhao , Jing Zhang , Yunpeng Bai , Jinxing Ye , Bo Bao , Xinggui Zhou , Li Zhang , Changlu Zhou , Xinhai Yu , Peng Zuo , Jianye Xia , Lian Cen , Yangyang Yang , Guoyue Shi , Lin Xu , Weiping Zhu , Yufang Xu , Xuhong Qian . Micro/nano flow chemistry by Beyond Limits Manufacturing. Chinese Chemical Letters, 2024, 35(5): 109020-. doi: 10.1016/j.cclet.2023.109020
11. [11]
  Huashan Huang , Jingze Chen , Luyun Zhang , Hong Yan , Siqi Li , Fen-Er Chen . Oscillatory flow reactor facilitates fast photochemical Wolff rearrangement toward synthesis of α-substituted amides in flow. Chinese Chemical Letters, 2025, 36(2): 109992-. doi: 10.1016/j.cclet.2024.109992
12. [12]
  Liliang Chu , Xiaoyan Zhang , Jianing Li , Xuelei Deng , Miao Wu , Ya Cheng , Weiping Zhu , Xuhong Qian , Yunpeng Bai . Continuous-flow synthesis of polysubstituted γ-butyrolactones via enzymatic cascade catalysis. Chinese Chemical Letters, 2024, 35(4): 108896-. doi: 10.1016/j.cclet.2023.108896
13. [13]
  Yuxin Xiao , Xiaowei Wang , Yutong Yin , Fangchao Yin , Jinchao Li , Zhiyuan Hou , Mashooq Khan , Rusong Zhao , Wenli Wu , Qiongzheng Hu . Distance-based lateral flow biosensor for the quantitative detection of bacterial endotoxin. Chinese Chemical Letters, 2024, 35(12): 109718-. doi: 10.1016/j.cclet.2024.109718
14. [14]
  Tianbo Jia , Lili Wang , Zhouhao Zhu , Baikang Zhu , Yingtang Zhou , Guoxing Zhu , Mingshan Zhu , Hengcong Tao . Modulating the degree of O vacancy defects to achieve selective control of electrochemical CO₂ reduction products. Chinese Chemical Letters, 2024, 35(5): 108692-. doi: 10.1016/j.cclet.2023.108692
15. [15]
  Kuangdi Luo , Yang Qin , Xuehao Zhang , Hanxu Ji , Heao Zhang , Jiangtian Li , Xianjin Xiao , Xinyu Wang . Regulable toehold lock for the effective control of strand displacement reaction sequence and circuit leakage. Chinese Chemical Letters, 2024, 35(7): 109104-. doi: 10.1016/j.cclet.2023.109104
16. [16]
  Meng Shan , Yongmei Yu , Mengli Sun , Shuping Yang , Mengqi Wang , Bo Zhu , Junbiao Chang . Bifunctional organocatalyst-catalyzed dynamic kinetic resolution of hemiketals for synthesis of chiral ketals via hydrogen bonding control. Chinese Chemical Letters, 2025, 36(1): 109781-. doi: 10.1016/j.cclet.2024.109781
17. [17]
  Xinyu Tian , Jiaxiang Guo , Zeyi Li , Shihou Sheng , Tianyu Zhang , Xianfei Li , Chuandong Dou . Control over electronic structures of organic diradicaloids via precise B/O-heterocycle fusion. Chinese Chemical Letters, 2025, 36(1): 110174-. doi: 10.1016/j.cclet.2024.110174
18. [18]
  Hongjie Guo , Qiang Wei , Yangyang Wu , Wei Qiu , Hongliang Li , Changyong Zhang . Enhanced nitrate removal from groundwater using a conductive spacer in flow-electrode capacitive deionization. Chinese Chemical Letters, 2024, 35(8): 109325-. doi: 10.1016/j.cclet.2023.109325
19. [19]
  Jinlong Li , Ruixin Li , Jiahui Liu , Ji-Quan Liu , Jia Xu , Xianglin Zhou , Yefan Zhang , Kairui Wang , Lin Lei , Gang Xie , Fengmei Wang , Ying Yang , Liping Cao . A TOC- and deposition-free electrochromic window driven by redox flow battery. Chinese Chemical Letters, 2024, 35(12): 110355-. doi: 10.1016/j.cclet.2024.110355
20. [20]
  Xiao Xiao , Biao Chen , Jia-Wei Li , Jun-Bo Zheng , Xu Wang , Hang Zhao , Fen-Er Chen . Nitrite-catalyzed economic and sustainable bromocyclization of tryptamines/tryptophols to access hexahydropyrrolo[2,3-b]indoles/tetrahydrofuroindolines in batch and flow. Chinese Chemical Letters, 2024, 35(7): 109280-. doi: 10.1016/j.cclet.2023.109280

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(843)
HTML views(36)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142