Citation: Fanglin Xue, Hengmao Liu, Rui Wang, Dan Zhang, Hao Song, Xiao-Yu Liu, Yong Qin. Enantioselective total synthesis of (+)-vincamine[J]. Chinese Chemical Letters, ;2022, 33(4): 2044-2046. doi: 10.1016/j.cclet.2021.09.032 shu

Enantioselective total synthesis of (+)-vincamine

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

songhao@scu.edu.cn

yongqin@scu.edu.cn

Received Date: 23 July 2021
Revised Date: 2 September 2021
Accepted Date: 7 September 2021
Available Online: 11 September 2021

Figures(5)

A catalytic asymmetric total synthesis of (+)-vincamine is presented. Key features of the synthesis include a Pd-catalyzed enantioselective decarboxylative allylation to form the C20 quaternary stereogenic center and a stereoselective iminium reduction to install the critical cis-C20/C21 relative stereochemisty.
- Indole alkaloid,
- Decarboxylative allylation,
- Stereoselective iminium reduction,
- Natural product,
- Total synthesis
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