Citation: Jiabin Shen, Jun Xu, Lei He, Chenfeng Liang, Wanmei Li. Application of Langlois' reagent (NaSO₂CF₃) in C–H functionalisation[J]. Chinese Chemical Letters, ;2022, 33(3): 1227-1235. doi: 10.1016/j.cclet.2021.09.005 shu

Application of Langlois' reagent (NaSO₂CF₃) in C–H functionalisation

College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou 311121, China

liwanmei@hznu.edu.cn

Received Date: 8 July 2021
Revised Date: 31 August 2021
Accepted Date: 1 September 2021
Available Online: 9 September 2021

Figures(28)

The process of selectively introducing a CF₃ group into an organic molecule using inexpensive, stable, and solid sodium trifluoromethanesulfinate has rapidly advanced in recent years to become an eco-friendly method used by organic chemists to synthesize various natural and bioactive molecules. This review focuses on advances made within the last five years regarding C–H functionalisation, namely thermochemical C(sp²)–H (thio)trifluoromethylations, photochemical C(sp²)–H trifluoromethylations, and electrochemical C(sp²)–H trifluoromethylations, using Langlois' reagent (NaSO₂CF₃).
- Trifluoromethylation,
- Langlois' reagent,
- Reaction mechanism,
- Synthetic method,
- C–H activation
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Application of Langlois' reagent (NaSO2CF3) in C–H functionalisation

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Application of Langlois' reagent (NaSO₂CF₃) in C–H functionalisation