Citation: Jianhua Yan, Yixuan Zhang, Lijuan Zheng, Yuwei Wu, Ting Wang, Ting Jiang, Xiaoqin Liu, Dongming Peng, Yanfei Liu, Zhenbao Liu. Let-7i miRNA and platinum loaded nano-graphene oxide platform for detection/reversion of drug resistance and synergetic chemical-photothermal inhibition of cancer cell[J]. Chinese Chemical Letters, ;2022, 33(2): 767-772. doi: 10.1016/j.cclet.2021.08.018 shu

Let-7i miRNA and platinum loaded nano-graphene oxide platform for detection/reversion of drug resistance and synergetic chemical-photothermal inhibition of cancer cell

Jianhua Yan ^a ,
Yixuan Zhang ^a ,
Lijuan Zheng ^a ,
Yuwei Wu ^a ,
Ting Wang ^a ,
Ting Jiang ^b ,
Xiaoqin Liu ^b ,
Dongming Peng ^c ,
Yanfei Liu ^{b, *,} ,
Zhenbao Liu ^{a, d, *,}

a.
Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
b.
Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
c.
Department of Medicinal Chemistry, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China
d.
Molecular Imaging Research Center of Central South University, Changsha 410008, China

liuyf@csu.edu.cn

zhenbaoliu@csu.edu.cn

Received Date: 11 June 2021
Revised Date: 3 August 2021
Accepted Date: 5 August 2021
Available Online: 11 August 2021

Figures(4)

The drug resistance of chemotherapy is a major challenge to overcome for antineoplastic agents and the reverse of drug resistant is essential for cancer therapy. Herein, we developed a drug delivery system which can simultaneously detect/reverse the drug resistance and perform synergetic treatment of cancer. In this work, we integrated cyanine5 (Cy5) modified miRNA (let-7i) (Cy5-miRNA) and platinum onto nano-graphene oxide (NGO) (30-50 nm) platform to achieve simultaneously detection/reversion of drug resistance and synergetic treatment of cisplatin resistant SKOV₃ cells (SKOV₃DDP cells). The Cy5-miRNA adsorbed on NGO could selectively bind the drug resistance related mRNA follow by suppress the expression of drug resistance mRNA, and the binding simultaneously induced the release of Cy5-miRNA from the NGO, thus the fluorescence signal of Cy5 recovered and could be used for drug resistance monitoring. Moreover, the miRNA suppressed the Cyclin D1 protein expressions thus reversed the drug resistance. The loaded platinum(IV) (Pt(IV)) was converted to the therapeutic platinum(II) (Pt(II)) in both tumor acidic and reductive environment responsive behavior. NGO furtherly performed photothermal therapy under near infrared (NIR) laser irradiation and enhanced the therapeutic effect. All in all, this nanoplatform realized detection/reversion of the drug resistance as well as synergetic chemical-photothermal treatment of ovarian cancer cells, which holds great promise in the treatment of drug resistant cancer cells.
- Nano-graphene oxide,
- Drug resistance,
- Synergetic chemical-photothermal therapy,
- miRNA,
- Platinum
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