Citation: Chi Zhang, Jingjing Jin, Ke Liu, Xuejuan Ma, Xinfeng Zhang. Carbon dots-peroxyoxalate micelle as a highly luminous chemiluminescence system under physiological conditions[J]. Chinese Chemical Letters, ;2021, 32(12): 3931-3935. doi: 10.1016/j.cclet.2021.05.050 shu

Carbon dots-peroxyoxalate micelle as a highly luminous chemiluminescence system under physiological conditions

College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China

xuejuanma@163.com

zhangxinfeng09@cdut.cn

Received Date: 8 March 2021
Revised Date: 21 May 2021
Accepted Date: 24 May 2021
Available Online: 31 May 2021

Figures(4)

Chemiluminescence (CL) has been widely used for bioanalysis owing to its high sensitivity, low background and simplicity. However, most of the CL systems need acidic/alkaline conditions or organic solvent to enhance their luminescent efficiency, and the non-physiological conditions can usually lead to the misfunction of biomolecules during biosensing. Herein, we report a highly luminous CL system under physiological conditions based on carbon dots-bis(2-carbopentyloxy-3, 5, 6-trichlorophenyl) oxalate (CDs-CPPO) micelles, and further used it in biosensing application. In the CL system, the amphiphilic surfactant packed CPPO and hydrophobic CDs together to form CDs-CPPO micelles. Such micelles solution not only isolated the CPPO from water to prevent its hydrolysis but also made the close proximity between CPPO and CDs, thus significantly enhancing the CDs quantum yield. The CL quantum yield was calculated to be 5.26 × 10⁻⁴ einsteins/mol, about 200-fold higher than that of the most commonly used luminol CL system. The oxidases (e.g., glucose oxidase) were tested to be susceptible to the organic solvent and non-physiological pH. Hence, the CL system was used for the detection of oxidase substrates (exemplified by glucose) in serum samples, and the limit of detection was as low as 8.4 nmol/L. The highly luminous CL system that can work under physiological conditions is promising for biosensing applications
- Carbon dots,
- Chemiluminescence,
- Micelle,
- Oxidase
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