Citation: Jingjing Wang, Xue Liu, Ziyan Wu, Feng Li, Tingting Qin, Siyuan Zhang, Weiguang Kong, Lantao Liu. Silver-catalyzed decarboxylative C-H functionalization of cyclic aldimines with aliphatic carboxylic acids[J]. Chinese Chemical Letters, ;2021, 32(9): 2777-2781. doi: 10.1016/j.cclet.2021.03.011 shu

Silver-catalyzed decarboxylative C-H functionalization of cyclic aldimines with aliphatic carboxylic acids

Jingjing Wang ^{a, **,} ,
Xue Liu ^c ,
Ziyan Wu ^a ,
Feng Li ^a ,
Tingting Qin ^a ,
Siyuan Zhang ^a ,
Weiguang Kong ^{b, **,} ,
Lantao Liu ^{a, c, *,}

a.
Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China
b.
College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China
c.
College of Chemistry, Zhengzhou University, Zhengzhou 450052, China

wangjingjing0918@163.com

17839550737@163.com

liult05@iccas.ac.cn

Received Date: 8 January 2021
Revised Date: 1 March 2021
Accepted Date: 3 March 2021
Available Online: 5 March 2021

Figures(6)

Silver-catalyzed decarboxylative C-H alkylation of cyclic aldimines with abundant aliphatic carboxylic acids has been realized under mild reaction conditions generating the corresponding products in moderate to good yields (32%-91%). In addition, a gram-scale reaction, late-stage modification of drug, synthetic transformation of the product, and further application of the catalytic strategy were also performed. Preliminary studies indicate that the reaction undergoes a radical process.
- Radical,
- Decarboxylation,
- C-H functionalization,
- Cyclic aldimines,
- Aliphatic carboxylic acids
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