Citation: Youzhe Chen, Chengbo Xu, Weiping Wang, Xiaoliang Wang, Qinglan Guo, Jiangong Shi. Phthalide-derived oxaspiroangelioic acids A–C with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head[J]. Chinese Chemical Letters, ;2021, 32(10): 3257-3260. doi: 10.1016/j.cclet.2021.03.004 shu

Phthalide-derived oxaspiroangelioic acids A–C with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

guonina@imm.ac.cn

shijg@imm.ac.cn

Received Date: 6 February 2021
Revised Date: 19 February 2021
Accepted Date: 1 March 2021
Available Online: 3 March 2021

Figures(4)

Three phthalide-derived analogues, oxaspiroangelioic acids A–C (1–3), were isolated as minor components of an aqueous extract of the Angelica sinensis root heads (guitou). Oxaspiroangelioic acids A and B were racemates separated into enantiomers by chiral HPLC. Their structures including absolute configurations were determined by spectroscopic data analysis, single crystal X-ray diffraction, exciton chirality method and electronic circular dichroism (ECD) calculation. These compounds share an undescribed carbon skeleton, for which biosynthetic pathways are proposed. Compound 1 and its enantiomers showed almost identical activity inhibiting Tandem of P domains in a weak inwardly rectifying K⁺ channel 1 (TREK-1).
- Umbelliferae,
- Angelica sinensis,
- Phthalide-derived analogues,
- Oxaspiroangelioic acids A–C
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