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Citation: Wei Huang, Ming-Liang Han, Yu-Wen Liu, Hui Xu, Hui-Xiong Dai. Palladium-catalyzed diarylative dearomatization of indoles with aryl thioesters[J]. Chinese Chemical Letters, ;2021, 32(9): 2765-2768. doi: 10.1016/j.cclet.2021.02.048 shu

Palladium-catalyzed diarylative dearomatization of indoles with aryl thioesters

Wei Huang ^a ,
Ming-Liang Han ^{d, e} ,
Yu-Wen Liu ^{b, c} ,
Hui Xu ^{b, **,} ,
Hui-Xiong Dai ^{b, c, *,}

a.
School of Pharmacy, Nanchang University, Nanchang 330006, China
b.
Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Shanghai 201203, China
c.
University of Chinese Academy of Sciences, Beijing 100049, China
d.
Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China
e.
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China

xuhui2018@simm.ac.cn

hxdai@simm.ac.cn

Received Date: 18 January 2021
Revised Date: 20 February 2021
Accepted Date: 22 February 2021
Available Online: 25 February 2021

Figures(3)

We report herein a palladium-catalyzed diarylative dearomatization of indole by employing thioester and arylboronic acid as the aryl electrophiles. The reaction involved a decarbonylation/migratory insertion/terminal Suzuki coupling procedure. Substrates bearing various functional groups are well tolerated in the reaction, affording the diarylated indoline skeletons in moderate to good yields.
- Thioester,
- Decarbonylation,
- Dearomatization,
- Indolines skeleton,
- Diarylation
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