Citation: Chunmei Wu, Tianyi Li, Dongju Li, Shanshan Jia, Jianmei Huang, Haimin Lei, Mei Zhang. Rapid detection of pesticide residues in Chinese herbal medicines by molecularly imprinted membrane electrospray ionization mass spectrometry[J]. Chinese Chemical Letters, ;2021, 32(7): 2174-2178. doi: 10.1016/j.cclet.2020.11.060 shu

Rapid detection of pesticide residues in Chinese herbal medicines by molecularly imprinted membrane electrospray ionization mass spectrometry

Chunmei Wu ^{a, 1} ,
Tianyi Li ^{b, 1} ,
Dongju Li ^c ,
Shanshan Jia ^a ,
Jianmei Huang ^a ,
Haimin Lei ^a ,
Mei Zhang ^{a, *,}

a.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China
b.
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
c.
Experimental Teaching Center, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China

meizhang@bucm.edu.cn

Received Date: 27 July 2020
Revised Date: 27 October 2020
Accepted Date: 25 November 2020
Available Online: 1 December 2020

Figures(3)

Chinese herbal medicines (CHMs) play an increasingly important role in the field of medicine and affects public health in the world. Although more and more strict has been employed to ensure the quality and safety of CHMs, pesticide residues in CHMs remain a serious issue and are the bottleneck for the global development of CHMs. In this work, we applied molecularly imprinted membrane electrospray mass spectrometry (MIM-ESI MS) for rapid detecting 4 classes of pesticide residues in CHMs, including organophosphorus (OPP), carbamates, pyrethroids and neonicotinoids in CHMs. Compared with our previous ambient ionization method MESI, MIM-ESI is capable of achieving a ~50-fold increase in the detection limit of conventional analytical methods owing to the specificity recognition and unique enrichment of MIM. The optimal experimental conditions were determined, and the method was further validated for its sensitivity and specificity. Our data showed that MIM-ESI MS is applicable for the direct quantitation of pesticide residues in CHMs. This detection technology may help to ensure the quality of CHMs in the future.
- Pesticides residue,
- Chinese herbal medicines (CHMs),
- Rapid detection,
- Molecularly imprinted membrane,
- Ambient ionization,
- Mass spectrometry
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