Citation: Pengzhan Wang, Huocheng Yang, Chang Liu, Mingqiang Qiu, Xin Ma, Zhiqiang Mao, Yao Sun, Zhihong Liu. Recent advances in the development of activatable multifunctional probes for in vivo imaging of caspase-3[J]. Chinese Chemical Letters, ;2021, 32(1): 168-178. doi: 10.1016/j.cclet.2020.11.056 shu

Recent advances in the development of activatable multifunctional probes for in vivo imaging of caspase-3

Pengzhan Wang ^{a, 1} ,
Huocheng Yang ^{b, c, 1} ,
Chang Liu ^{b, c, 1} ,
Mingqiang Qiu ^{c, *,} ,
Xin Ma ^d ,
Zhiqiang Mao ^{a, *,} ,
Yao Sun ^{c, *,} ,
Zhihong Liu ^a

a.
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules & College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China
b.
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Xinjiang 830011, China
c.
International Joint Research Center for Intelligent Biosensor Technology and Health, Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China
d.
State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

qiumingqiang@mail.ccnu.edu.cn

maozq@hubu.edu.cn

sunyaogbasp@mail.ccnu.edu.cn

Received Date: 28 September 2020
Revised Date: 23 November 2020
Accepted Date: 24 November 2020
Available Online: 30 November 2020

Figures(9)

Caspases are a family of proteases that play critical roles in controlling inflammation and cell death. Apoptosis is a caspase-3 mainly controlled behavior to avoid inflammation and damage to surrounding cells, whereas anomalistic cell apoptosis may be associated with many diseases. The detection and imaging of caspase-3 will be of great significance in evaluating the early therapeutic effect of tumors. Developing smart fluorescent probes may be helpful for the visualization of therapeutic effect compared with palways onq probes. Thus, more and more works toward activatable fluorescent probes for caspase-3 imaging have been reported. In addition, multifunctional probes have also been designed to further improve the imaging of caspase-3. Herein, this review systematically summarized the representative work of caspase-3 from the perspective of molecular design that it will play a guiding role in the design of probes that respond to caspase-3. Also, challenges and perspectives toward the field for imaging of cell apoptosis (caspase-3) are also discussed.
- Fluorescence imaging,
- Multi-functional,
- Activatable probe,
- Caspase-3
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沈阳化工大学材料科学与工程学院沈阳 110142