Citation: Sheng Yu, Yaqi Wang, Sobhan Chatterjee, Feng Liang, Fei Zhu, Haibing Li. Pillar[5]arene-functionalized nanochannel platform for detecting chiral drugs[J]. Chinese Chemical Letters, ;2021, 32(1): 179-183. doi: 10.1016/j.cclet.2020.11.055 shu

Pillar[5]arene-functionalized nanochannel platform for detecting chiral drugs

Sheng Yu ^{a, 1} ,
Yaqi Wang ^{a, 1} ,
Sobhan Chatterjee ^a ,
Feng Liang ^{a, *,} ,
Fei Zhu ^b ,
Haibing Li ^{b, *,}

a.
The State Key Laboratory of Refractories and Metallurgy, School of Chemistry & Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China
b.
Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China

feng_liang@wust.edu.cn

lhbing@mail.ccnu.edu.cn

Received Date: 24 September 2020
Revised Date: 16 November 2020
Accepted Date: 18 November 2020
Available Online: 1 December 2020

Figures(5)

Chirality is a fascinating and essential feature of life and highly associated with many significant pharmaceutical, chemical, and biological processes. The construction of chiral recognition platform is a hot research topic and challenging assignment. Herein, we report an electrochemical method by differential pulse voltammetry (DPV) for the enantioselective recognition of chiral drug propranolol (R/S-PPL) through a nanochannel platform based on the N-acetyl-L-cysteine functionalized Pillar[5]arenes derivative NALC-P5 and the porous polycarbonate membrane. The chiral discrimination depends on the difference in the supramolecular host-guest interaction between the chiral NALC-P5 and the R/S-PPL. The transmission rate of the R/S-PPL can be regulated in the nanochannel and we can achieve the selective transport of the chiral drugs. This simple electrochemical technique has potential applications as a general platform for the recognition of chiral molecules.
- Chiral recognition,
- Pillar[5]arene,
- Bionic nanochannel,
- Electrochemical sensor,
- Chiral drugs
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