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Citation: Kaida Zhou, Jiapian Huang, Jie Wu, Guanyinsheng Qiu. An unexpected iron(Ⅱ)-promoted reaction of N-arylprop-2-yn-1-imines with water: Facile assembly of multi-substituted pyrroles[J]. Chinese Chemical Letters, ;2021, 32(1): 37-39. doi: 10.1016/j.cclet.2020.11.049 shu

An unexpected iron(Ⅱ)-promoted reaction of N-arylprop-2-yn-1-imines with water: Facile assembly of multi-substituted pyrroles

  • a.

    School of Pharmaceutical and Materials Engineering & Institute for Advanced Studies, Taizhou University, Taizhou 318000, China

  • b.

    State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

  • c.

    College of Biological, Chemical Science and Engineering, Jiaxing University, Jiaxing 314001, China

    * Corresponding author at: School of Pharmaceutical and Materials Engineering & Institute for Advanced Studies, Taizhou University, Taizhou 318000, China.
    ** Corresponding author.
    E-mail addresses: jie_wu@fudan.edu.cn (J. Wu), qiuguanyinsheng@mail.zjxu.edu.cn (G. Qiu).
  • Received Date: 7 September 2020
    Revised Date: 20 November 2020
    Accepted Date: 25 November 2020
    Available Online: 1 December 2020

Figures(3)

  • Generation of multi-substituted pyrroles is accomplished through an unexpected iron(Ⅱ)-promoted reaction of N-arylprop-2-yn-1-imines with water. This transformation proceeds smoothly with excellent chemoselectivity and regioselectivity. A stoichiometric amount of Fe(OTf)2 is necessary for the successful conversion. A Lewis acid-promoted tandem reaction pathway is proposed.
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