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Citation: Hui Liu, Yuzhuo Wu, Qinglan Guo, Shuai Shao, Chengbo Xu, Tiantai Zhang, Jiangong Shi. Aconapelsulfonines A and B, seco C20-diterpenoid alkaloids deriving via Criegee rearrangements of napelline skeleton from Aconitum carmichaelii[J]. Chinese Chemical Letters, ;2021, 32(1): 33-36. doi: 10.1016/j.cclet.2020.09.062 shu

Aconapelsulfonines A and B, seco C20-diterpenoid alkaloids deriving via Criegee rearrangements of napelline skeleton from Aconitum carmichaelii

  • State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

    * Corresponding authors.
    E-mail addresses: ttzhang@imm.ac.cn (T. Zhang), shijg@imm.ac.cn (J. Shi).
    1 These authors contributed equally to this work.
  • Received Date: 4 August 2020
    Revised Date: 8 September 2020
    Accepted Date: 30 September 2020
    Available Online: 1 October 2020

Figures(5)

  • Two sulfonated seco C20-diterpenoid alkaloids, aconapelsulfonines A (1) and B (2), were isolated from an aqueous extract of the raw material of "Fu Zi" (the Aconitum carmichaelii lateral roots), of which the structures were elucidated by various spectroscopic data, combined with X-ray crystallographic analysis. The unprecedented skeletons are biogenetically proposed to be derived via Criegee rearrangements of the napelline-type architecture. The two compounds exhibited dose-depended analgesic activities on an acetic acid-induced mice writhing test.
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