Citation: Honghong Rao, Xin Xue, Mingyue Luo, Haixia Liu, Zhonghua Xue. Recent advances in the development of colorimetric analysis and testing based on aggregation-induced nanozymes[J]. Chinese Chemical Letters, ;2021, 32(1): 25-32. doi: 10.1016/j.cclet.2020.09.017 shu

Recent advances in the development of colorimetric analysis and testing based on aggregation-induced nanozymes

Honghong Rao ^{a, *,} ,
Xin Xue ^{b, *,} ,
Mingyue Luo ^b ,
Haixia Liu ^a ,
Zhonghua Xue ^b

a.
College of Chemistry & Chemical Engineering, Lanzhou City University, Lanzhou 730070, China
b.
Key Laboratory of Bioelectrochemistry & Environmental Analysis of Gansu Province, College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou 730070, China

rhh@nwnu.edu.cn

xzh@nwnu.edu.cn

Received Date: 27 June 2020
Revised Date: 2 August 2020
Accepted Date: 14 September 2020
Available Online: 15 September 2020

Figures(8)

Colorimetric sensing strategies as a powerful point-of-care testing (POCT) tool have attracted significant interest in various chem/biosensing applications. Taking the excellent bare-eye-detectable signaling feature, nanozymes-based colorimetric sensors enable more potential applications and have been a new forefront in the colorimetric POCT analysis toward different target analytes. However, the low catalytic activity of nanozymes in most cases limits their practical application. Recent efforts demonstrate that the aggregation-induced nanozymes provide a general means to modulate nanozymes activity and enhance colorimetric sensing performances of some nanozymes-based colorimetric sensors. But there are few reports are explored to discuss and review such aggregation-induced nanozymes and their colorimetric sensing applications. To highlight the advances and progress in aggregation-induced nanozymes based colorimetric assays, we herein summary the fundamentals, classify and applications of this newly-developing field, focusing on the aggregation-induced activity enhancement of nanozymes (AIAE-nanozymes) with a significant "signal-on" feature and aggregation-induced activity inhibition of nanozymes (AIAI-nanozymes) with a dramatical "signal-off" characteristics. Finally, we also propose the current challenges and the future prospects on both AIAE-nanozymes and AIAI-nanozymes.
- Colorimetry,
- Nanozymes,
- Aggregation-induced effect,
- Point-of-care testing,
- Naked eye
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沈阳化工大学材料科学与工程学院沈阳 110142