Citation: Mengmeng Hou, Yuanxin Zhong, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue. Polydopamine (PDA)-activated cobalt sulfide nanospheres responsive to tumor microenvironment (TME) for chemotherapeutic-enhanced photothermal therapy[J]. Chinese Chemical Letters, ;2021, 32(3): 1055-1060. doi: 10.1016/j.cclet.2020.08.009 shu

Polydopamine (PDA)-activated cobalt sulfide nanospheres responsive to tumor microenvironment (TME) for chemotherapeutic-enhanced photothermal therapy

Mengmeng Hou ^{a, 1} ,
Yuanxin Zhong ^{a, 1} ,
Lei Zhang ^b ,
Zhigang Xu ^a ,
Yuejun Kang ^a ,
Peng Xue ^a,

a.
School of Materials and Energy, Southwest University, Chongqing 400715, China
b.
State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China

Received Date: 24 June 2020
Revised Date: 21 July 2020
Accepted Date: 6 August 2020
Available Online: 8 August 2020

Figures(5)

Most recently, cobalt sulfide (CoS) nanospheres (NSs) have been demonstrated as an ideal high-efficient photothermal agent for tumor elimination. However, the surface of CoS NSs is lack of functional chemical groups or active radicals to incorporate therapeutic agents, which tremendously hinders their versatile utilization in medical field. Here, surface activation of CoS NSs was realized through the growth of polydopamine (PDA) in situ via alkaline-triggered polymerization. Upon the formation of CoS@PDA NSs, thiol-polyethylene glycol (SH-PEG) and chemotherapeutic agent of doxorubicin (DOX) were loaded onto the particle surface by means of π-π electrostatic interaction and Michael addition reactions. As-synthesized CoS@PDA/PEG/DOX (CoPPD) NSs exhibited an admirable photothermal property and high loading capacity of DOX (44.6%). Furthermore, drug release can be accelerated under a more acidic pH condition mimicking tumor microenvironment (TME), ascribed to the protonation of amino group in DOX molecules. Finally, a strong chemotherapeutic-enhanced photothermal therapeutic effect was demonstrated toward solid tumor under near-infrared (NIR) light irradiation without causing significant systemic toxicity. In this regard, this paradigm may offer valuable guidance for the design of multifunctional CoS-based nanoagents for medical treatment.
- Cobalt sulfide nanospheres,
- Polydopamine,
- Tumor microenvironment,
- Drug delivery,
- Combination therapy
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