Citation: Li Qian, Lu Xiaoyun. New antituberculosis drugs targeting the respiratory chain[J]. Chinese Chemical Letters, ;2020, 31(6): 1357-1365. doi: 10.1016/j.cclet.2020.04.007 shu

New antituberculosis drugs targeting the respiratory chain

Li Qian ,
Lu Xiaoyun ^*,

International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE), School of Pharmacy, Ji'nan University, Guangzhou 510632, China

luxy2016@jnu. edu. cn

Received Date: 5 March 2020
Revised Date: 31 March 2020
Accepted Date: 6 April 2020
Available Online: 12 April 2020

Figures(14)

With the emergence of multidrug-resistant tuberculosis and extensive drug-resistant tuberculosis strains, there is an urgent need to develop novel drugs for the treatment of tuberculosis. The respiratory chain is a promising target for the development of new antimycobacterial agents, and a growing number of compounds have been reported and some have entered clinical trials. In this review, we summarize the main features and the electron transfer process of the mycobacterial respiratory chain, and the recent progress in the search for new small molecule inhibitors targeting the three main potential targets in the respiratory chain of Mycrobacterium tuberculosis. Our emphasis is on the optimization strategy of QcrB inhibitors and the challenges of developing QcrB inhibitors as antituberculosis drugs due to the alternate bd-type oxidase oxidative compensation pathway are discussed.
- Respiratory chain,
- Antituberculosis drug,
- QcrB,
- NADH-2,
- ATP synthase
1. [1]
  T. Wirth, F. Hildebrand, C. Allix-Beguec, et al., PLoS Pathog4 (2008)e1000160. doi: 10.1371/journal.ppat.1000160
2. [2]
  World Health Organization, Global Tuberculosis Report 2019 (WHO), https://www.who.int/tb/publications/global_report/en/.
3. [3]
  L. Pitance, L. Vecellio, T. Leal, et al., J. Aerosol. Med. Pulm. D. 23 (2010) 389-396. doi: 10.1089/jamp.2010.0816
4. [4]
  K. Andries, P. Verhasselt, J. Guillemont, et al., Science 307 (2005) 223-227. doi: 10.1126/science.1106753
5. [5]
  A. H. Diacon, P. R. Donald, A. Pym, et al., Antimicrob Agents Ch. 56 (2012) 3271-3276. doi: 10.1128/AAC.06126-11
6. [6]
  E. Cox, K. Laessig, N. Engl. J. Med. 371 (2014) 689-691. doi: 10.1056/NEJMp1314385
7. [7]
  M. T. Gler, V. Skripconoka, E. Sanchez-Garavito, et al., N. Engl. J. Med. 366 (2012) 2151-2160. doi: 10.1056/NEJMoa1112433
8. [8]
  C. D. Tweed, R. Dawson, D. A. Burger, et al., Lancet Respir. Med. 7 (2019) 1048-1058. doi: 10.1016/S2213-2600(19)30366-2
9. [9]
  C. G. Mohan, Impact of Target-Based Drug Design in Anti-bacterial Drug Discovery for the Treatment of Tuberculosis, Springer, 2019, pp. 307-346.
10. [10]
  K. Mdluli, T. Kaneko, A. Upton, Cold Spring Harb. Perspect. Med. 5 (2015) a021154. doi: 10.1101/cshperspect.a021154
11. [11]
  S. L. Tran, G. M. Cook, J. Bacteriol. 187 (2005) 5023-5028. doi: 10.1128/JB.187.14.5023-5028.2005
12. [12]
  C. A. Kerantzas, W. R. Jacobs Jr., mBio 8 (2017) e01586-16.
13. [13]
  G. Sotgiu, G. Sulis, A. Matteelli, Microbiol. Spectr. 5 (2017) TNMI7-0036-2016.
14. [14]
  D. Bald, A. Koul, FEMS Microbiol. Lett. 308 (2010) 1-7. doi: 10.1111/j.1574-6968.2010.01959.x
15. [15]
  S. Kerscher, S. Dröse, V. Zickermann, U. Brandt, ResultsProbl. CellDiffer. 45 (2008) 185-222.
16. [16]
  E. A. Weinstein, T. Yano, L. S. Li, et al., Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 4548-4553. doi: 10.1073/pnas.0500469102
17. [17]
  G. Unden, J. Bongaerts, Biochim. Biophys. Acta 1320 (1997) 217-234. doi: 10.1016/S0005-2728(97)00034-0
18. [18]
  S. P. S. Rao, S. Alonso, L. Rand, T. Dick, K. Pethe, Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 11945-11950. doi: 10.1073/pnas.0711697105
19. [19]
  L. Miesel, T. R. Weisbrod, J. A. Marcinkeviciene, R. Bittman, W. R. Jacobs Jr., J. Bacteriol. 180 (1998) 2459-2467. doi: 10.1128/JB.180.9.2459-2467.1998
20. [20]
  D. Bald, C. Villellas, P. Lu, A. Koul, mBio 8 (2017) e00272-17.
21. [21]
  C. Pidathala, R. Amewu, B. Pacorel, et al., J. Med. Chem. 55 (2012) 1831-1843.
22. [22]
  R. Cox, G. Cook, Curr. Mol. Med. 7 (2007) 231-245. doi: 10.2174/156652407780598584
23. [23]
  L. G. Matsoso, B. D. Kana, P. K. Crellin, et al., J. Bacteriol. 187 (2005) 6300-6308. doi: 10.1128/JB.187.18.6300-6308.2005
24. [24]
  H. Gong, J. Li, A. Xu, et al., Science 362 (2018) eaat8923. doi: 10.1126/science.aat8923
25. [25]
  K. A. Abrahams, J. A. Cox, V. L. Spivey, et al., PLoS One 7 (2012) e52951. doi: 10.1371/journal.pone.0052951
26. [26]
  P. A. Mak, S. P. Rao, M. P. Tan, et al., ACS Chem. Biol. 7 (2012) 1190-1197. doi: 10.1021/cb2004884
27. [27]
  S. Kang, R. Y. Kim, M. J. Seo, et al., J. Med. Chem. 57 (2014) 5293-5305.
28. [28]
  K. Pethe, P. Bifani, J. Jang, et al., Nat. Med. 19 (2014) 1157-1160.
29. [29]
  V. B. Borisov, R. Murali, M. L. Verkhovskaya, et al., Proc. Natl. Acad. Sci. U. S. A. 108 (2011) 17320. doi: 10.1073/pnas.1108217108
30. [30]
  V. B. Borisov, R. B. Gennis, J. Hemp, M. I. Verkhovsky, Biochim. Biophys. Acta 1807 (2011) 1398-1413. doi: 10.1016/j.bbabio.2011.06.016
31. [31]
  L. Shi, C. D. Sohaskey, B. D. Kana, et al., Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 15629. doi: 10.1073/pnas.0507850102
32. [32]
  P. Lu, M. Heineke, A. Koul, et al., Sci. Rep. 5 (2015) 10333. doi: 10.1038/srep10333
33. [33]
  K. Arora, B. Ochoa-Montano, P. S. Tsang, et al., Antimicrob. Agents Chemother. 58 (2014) 6962-6965. doi: 10.1128/AAC.03486-14
34. [34]
  C. von Ballmoos, G. Cook, P. Dimroth, Ann. Rev. Biophys. 37 (2008) 43-64. doi: 10.1146/annurev.biophys.37.032807.130018
35. [35]
  D. Pogoryelov, O. Yildiz, J. D. Faraldo-Gomez, T. Meier, Nat. Struct. Mol. Biol. 16 (2009) 1068-1073. doi: 10.1038/nsmb.1678
36. [36]
  M. Diez, B. Zimmermann, M. Börsch, et al., Nat. Struct. Mol. Biol. 11 (2004) 135-141. doi: 10.1038/nsmb718
37. [37]
  H. Noji, R. Yasuda, M. Yoshida, K. Kinosita Jr., Nature 386 (1997) 299-302. doi: 10.1038/386299a0
38. [38]
  J. K. Hakulinen, A. L. Klyszejko, J. Hoffmann, et al., Proc. Natl. Acad. Sci. U. S. A. 109 (2012) e2050-2056. doi: 10.1073/pnas.1203971109
39. [39]
  A. C. Haagsma, I. Podasca, A. Koul, et al., PLoS One 6 (2011) e23575. doi: 10.1371/journal.pone.0023575
40. [40]
  A. Koul, N. Dendouga, K. Vergauwen, et al., Nat. Chem. Biol. 3 (2007) 323-324. doi: 10.1038/nchembio884
41. [41]
  D. Ordway, M. Viveiros, C. Leandro, et al., L. Antimicrob Agents Chemother. 47 (2003) 917-922. doi: 10.1128/AAC.47.3.917-922.2003
42. [42]
  S. Sellamuthu, M. Singh, A. Kumar, S. K. Singh, Expert. Opin. Ther. Tar. 21 (2017) 559-570. doi: 10.1080/14728222.2017.1327577
43. [43]
  M. Kaminska, Folia med Craco. 9 (1967) 115-143.
44. [44]
  T. Yano, L. S. Li, E. Weinstein, J. S. Teh, H. Rubin, J. Biol. Chem. 281 (2006) 11456-11463. doi: 10.1074/jbc.M508844200
45. [45]
  M. Viveiros, S. Bosne-David, L. Amaral, Int. J. Antimicrob. Agents 16 (2000) 69-71. doi: 10.1016/S0924-8579(00)00199-0
46. [46]
  E. A. Dunn, M. Roxburgh, L. Larsen, et al., Bioorg. Med. Chem. 22 (2014) 5320-5328. doi: 10.1016/j.bmc.2014.07.050
47. [47]
  B. Lechartier, S. T. Cole, AntimicrobAgentsChemother 59 (2015) 4457-4463.
48. [48]
  T. Yano, S. Kassovska-Bratinova, J. Teh, et al., J. Biol. Chem. 286 (2011) 10276-10287. doi: 10.1074/jbc.M110.200501
49. [49]
  J. H. Grosset, S. Tyagi, D. V. Almeida, et al., Am. J. Respir. Crit. Care Med. 188 (2013) 608-612. doi: 10.1164/rccm.201304-0753OC
50. [50]
  D. A. Lamprecht, P. M. Finin, M. A. Rahman, et al., Nat. Commun. 7 (2016) 12393-12393. doi: 10.1038/ncomms12393
51. [51]
  D. Zhang, Y. Lu, K. Liu, et al., J. Med. Chem. 55 (2012) 8409-8417.
52. [52]
  D. Zhang, Y. Liu, C. Zhang, et al., Molecules 19 (2014) 4380-4394. doi: 10.3390/molecules19044380
53. [53]
  J. Xu, B. Wang, L. Fu, et al., Antimicrob. Agents Chemother. 63 (2019) e02155-02118.
54. [54]
  P. Shirude, B. Paul, N. Choudhury, et al., ACS Med. Chem. Lett. 3 (2012) 736-740. doi: 10.1021/ml300134b
55. [55]
  M. B. Harbut, B. Yang, R. Liu, et al., Angew. Chem. Int. Ed. Engl. 57 (2018) 3478-3482. doi: 10.1002/anie.201800260
56. [56]
  G. C. Moraski, L. D. Markley, P. A. Hipskind, et al., ACS Med. Chem. Lett. 2 (2011) 466-470. doi: 10.1021/ml200036r
57. [57]
  Z. No, J. Kim, P. B. Brodin, et al., WO2011113606A1 (2011).
58. [58]
  S. Kang, R. Y. Kim, M. J. Seo, et al., J. Med. Chem. 57 (2014) 5293-5305.
59. [59]
  http://www.newtbdrug.org/pipeline/clinical.
60. [60]
  N. P. Kalia, E. J. Hasenoehrl, N. B. Ab Rahman, et al., Proc. Natl. Acad. Sci. U. S. A. 114 (2017) 7426-7431. doi: 10.1073/pnas.1706139114
61. [61]
  P. Lu, A. Asseri, M. Kremer, et al., Sci. Rep. 8 (2018) 2625. doi: 10.1038/s41598-018-20989-8
62. [62]
  T. O'Malley, T. Alling, J. V. Early, et al., Antimicrob. Agents Chemother. 62 (2018) e02439-17.
63. [63]
  G. C. Moraski, L. D. Markley, J. Cramer, et al., ACS Med. Chem. Lett. 4 (2013) 675-679. doi: 10.1021/ml400088y
64. [64]
  Y. Cheng, G. C. Moraski, J. Cramer, M. J. Miller, J. S. Schorey, PLoS One 9 (2014) e87483. doi: 10.1371/journal.pone.0087483
65. [65]
  G. C. Moraski, P. A. Miller, M. A. Bailey, et al., ACS Infect. Dis. 1 (2015) 85-90.
66. [66]
  Z. Wu, Y. Lu, L. Li, et al., ACS Med. Chem. Lett. 7 (2016) 1130-1133. doi: 10.1021/acsmedchemlett.6b00330
67. [67]
  J. Tang, B. Wang, T. Wu, et al., ACS Med. Chem. Lett. 6 (2015) 814-818. doi: 10.1021/acsmedchemlett.5b00176
68. [68]
  X. Lu, J. Tang, Z. Liu, et al., Bioorg. Med. Chem. 26 (2016) 5916-5919. doi: 10.1016/j.bmcl.2016.11.003
69. [69]
  X. Lu, Z. Williams, K. Hards, et al., ACS Infect. Dis. 5 (2019) 239-249. doi: 10.1021/acsinfecdis.8b00225
70. [70]
  A. M. Upton, S. Cho, T. J. Yang, et al., Antimicrob. Agents Chemother. 59 (2015) 136-144. doi: 10.1128/AAC.03823-14
71. [71]
  X. Hu, B. Wan, Y. Liu, et al., ACS Med. Chem. Lett. 10 (2015) 295-299.
72. [72]
  J. Rybniker, A. Vocat, C. Sala, et al., Nat. Commun. 6 (2015) 7659. doi: 10.1038/ncomms8659
73. [73]
  L. Ballell, R. H. Bates, R. J. Young, et al., ChemMedChem 8 (2013) 313-321. doi: 10.1002/cmdc.201200428
74. [74]
  C. S. Foo, A. Lupien, M. Kienle, et al., mBio. 9 (2018) e01276-18.
75. [75]
  L. A. T. Cleghorn, P. C. Ray, J. Odingo, et al., J. Med. Chem. 61 (2018) 6592-6608.
76. [76]
  R. van der Westhuyzen, S. Winks, C. R. Wilson, et al., J. Med. Chem. 58 (2015) 9371-9381.
77. [77]
  N. S. Chandrasekera, T. Alling, M. A. Bailey, et al., J. Med. Chem. 58 (2015) 7273-7285.
78. [78]
  A. E. M. B. Gregory, A. Harrison, M. Singh, et al., mSphere 4 (2019) e00606-19.
79. [79]
  A. Lupien, C. S. Y. Foo, S. Savina, et al., PLoS Pathog. 16 (2020) e1008270. doi: 10.1371/journal.ppat.1008270
80. [80]
  L. Preiss, J. D. Langer, Ö. Yildiz, et al., Sci. Adv. 1 (2015) e1500106. doi: 10.1126/sciadv.1500106
81. [81]
  E. B. Chahine, L. R. Karaoui, H. Mansour, Ann. Pharmacother. 48 (2014) 107-115. doi: 10.1177/1060028013504087
82. [82]
  A. K. Kakkar, N. Dahiya, Tuberculosis (Edinb) 94 (2014) 357-362. doi: 10.1016/j.tube.2014.04.001
83. [83]
  H. Patel, R. Pawara, K. Pawara, et al., Tuberculosis (Edinb) 117 (2019) 79-84. doi: 10.1016/j.tube.2019.06.005
84. [84]
  J. Guillemont, C. Meyer, A. Poncelet, X. Bourdrez, K. Andries, Future Med. Chem. 3 (2011) 1345-1360. doi: 10.4155/fmc.11.79
85. [85]
  A. S. T. Tong, P. J. Choi, A. Blaser, et al., ACS Med. Chem. Lett. 8 (2011) 1019-1024.
86. [86]
  P. J. Choi, H. S. Sutherland, A. S. T. Tong, et al., Bioorg. Med. Chem. 27 (2017) 5190-5196. doi: 10.1016/j.bmcl.2017.10.042
87. [87]
  H. S. Sutherland, A. S. T. Tong, P. J. Choi, et al., Bioorg. Med. Chem. 26 (2018) 1797-1809. doi: 10.1016/j.bmc.2018.02.026
88. [88]
  A. Blaser, H. S. Sutherland, A. S. T. Tong, et al., Bioorg. Med. Chem. 27 (2019) 1283-1291. doi: 10.1016/j.bmc.2019.02.025
89. [89]
  H. S. Sutherland, A. S. T. Tong, P. J. Choi, et al., Bioorg. Med. Chem. 27 (2019) 1292-1307. doi: 10.1016/j.bmc.2019.02.026
90. [90]
  H. S. Sutherland, A. S. T. Tong, P. J. Choi, et al., Bioorg. Med. Chem. 28 (2020) 115213. doi: 10.1016/j.bmc.2019.115213
91. [91]
  J. P. Sarathy, P. Ragunathan, J. Shin, et al., Antimicrob. Agents Chemother. 63 (2019) e01191-01119.
92. [92]
  S. J. Tantry, S. D. Markad, V. Shinde, et al., J. Med. Chem. 60 (2017) 1379-1399.
93. [93]
  S. Kumar, R. Mehra, S. Sharma, et al., Tuberculosis (Edinb). 108 (2018) 56-63. doi: 10.1016/j.tube.2017.10.008
94. [94]
  S. Singh, K. K. Roy, S. R. Khan, et al., Bioorg. Med. Chem. 23 (2015) 742-752. doi: 10.1016/j.bmc.2014.12.060
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