Citation: Liu Guiting, Bao Ziting, Wu Jun. Injectable baicalin/F127 hydrogel with antioxidant activity for enhanced wound healing[J]. Chinese Chemical Letters, ;2020, 31(7): 1817-1821. doi: 10.1016/j.cclet.2020.03.005 shu

Injectable baicalin/F127 hydrogel with antioxidant activity for enhanced wound healing

Liu Guiting ^a,1 ,
Bao Ziting ^a,1 ,
Wu Jun ^a,b,*,

a.
Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, China
b.
Research Institute of Sun Yat-sen University in Shenzhen, Shenzhen 518057, China

wujun29@mail.sysu.edu.cn

Received Date: 11 January 2020
Revised Date: 28 February 2020
Accepted Date: 2 March 2020
Available Online: 3 March 2020

Figures(4)

Baicalin, extracted from traditional Chinese medicine Scutellaria baicalensis Georg, possesses multiple pharmacological activities and has great potential for chronic skin wound repair. However, the poor solubility and lack of suitable vehicles greatly limit its further application. Herein, we proposed a convenient and robust strategy, employing PBS solution as solvent, to enhance the solubility of baicalin. Furthermore, we constructed injectable baicalin/F127 hydrogels to study their application in skin wound treatment. The composition and temperature sensitivity of baicalin/Pluronic^® F-127 hydrogels were confirmed by FTIR and rheological testing, respectively. In vitro release measurement indicated that the first order model was best fitted with the release profile of baicalin from hydrogel matrix. Besides, MTT assay, AO/EO staining assay as well as hemolytic activity test revealed the excellent cytocompatibility of baicalin/F127 hydrogels. Antioxidant activity assay demonstrated the cytoprotective activity of baicalin/ F127 hydrogels against reactive oxygen species (ROS). Furthermore, the in vivo experiments exhibited the ability of baicalin/F127 hydrogel to accelerate wound healing. In conclusion, this novel injectable baicalin/F127 hydrogel should have bright application for chronic wound treatment.
- Wound healing,
- Hydrogel,
- Baicalin,
- Antioxidant,
- Injectable
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