Citation: Yang Yahui, Wang Yifan, Xu Ligeng, Chen Tianfeng. Dual-functional Se/Fe complex facilitates TRAIL treatment against resistant tumor cells via modulating cellular endoplasmic reticulum stress[J]. Chinese Chemical Letters, ;2020, 31(7): 1801-1806. doi: 10.1016/j.cclet.2020.03.004 shu

Dual-functional Se/Fe complex facilitates TRAIL treatment against resistant tumor cells via modulating cellular endoplasmic reticulum stress

Department of Chemistry, Jinan University, Guangzhou 510632, China

lgxu19@jnu.edu.cn

tchentf@jnu.edu.cn

Received Date: 26 December 2019
Revised Date: 28 February 2020
Accepted Date: 2 March 2020
Available Online: 3 March 2020

Figures(6)

Tumor cell resistance is one of the big hurdles limiting the therapeutic efficacy of tumor necrosis factorrelated apoptosis-inducing ligand (TRAIL)-based cancer treatment. Therefore, the development of a safe and effective sensitizer agent is greatly desired for optimizing TRAIL therapy. Herein, we successfully developed a Se/Fe complex with low toxicity to highly effectively inhibit tumor cells proliferation and migration capabilities through down-regulating ER stress related selenoproteins. Furthermore, it could more efficiently damage tumor spheroids with good penetration capability. More importantly, it could synergize with TRAIL treatment to induce the robust generation of reactive oxygen species (ROS), downregulating ER stress related selenoproteins for triggering tumor cells apoptosis in extrinsic and intrinsic signaling pathways. Taken together, this study provides a potential chemo-drug and sensitizer agent to improve the therapeutic efficacy of TRAIL-based cancer treatment.
- Se/Fe complex,
- TRAIL,
- ER stress,
- ROS,
- Cancer treatment
1. [1]
  S. von Karstedt, A. Montinaro, H. Walczak, Nat. Rev. Cancer 17 (2017) 352-366. doi: 10.1038/nrc.2017.28
2. [2]
  G.L. Wang, X.M. Wang, H. Yu, et al., Nat. Chem. Biol. 9 (2013) 84-89. doi: 10.1038/nchembio.1153
3. [3]
  J. Wiezorek, P. Holland, J. Graves, Clin. Cancer Res. 16 (2010) 1701-1708. doi: 10.1158/1078-0432.CCR-09-1692
4. [4]
  J. Eberle, Cancers 11 (2019) 656. doi: 10.3390/cancers11050656
5. [5]
  M.L. Plissonnier, S. Fauconnet, H. Bittard, et al., Oncotarget 8 (2017) 107744-107762. doi: 10.18632/oncotarget.22632
6. [6]
  S.R. Im, Y.J. Jang, Biochem. Biophys. Res. Commun. 424 (2012) 65-70. doi: 10.1016/j.bbrc.2012.06.067
7. [7]
  S.C. Gupta, S. Reuter, K. Phromnoi, et al., J. Biol. Chem. 286 (2011) 1134-1146. doi: 10.1074/jbc.M110.191379
8. [8]
  X.F. Chen, H. Thakkar, F. Tyan, et al., Oncogene 20 (2001) 6073-6083. doi: 10.1038/sj.onc.1204736
9. [9]
  K. Selvarajoo, Prog. Biophys. Mol. Biol. 128 (2017) 142-154. doi: 10.1016/j.pbiomolbio.2017.02.009
10. [10]
  X. Li, M. You, Y.J. Liu, et al., Sci. Rep. 7 (2017) 42748. doi: 10.1038/srep42748
11. [11]
  C.J. Liang, Y.C. Xu, G.M. Li, et al., OncoTargets Ther. 10 (2017) 417-428. doi: 10.2147/OTT.S127202
12. [12]
  J.R. Cubillos-Ruiz, S.E. Bettigole, L.H. Glimcher, Cell 168 (2017) 692-706. doi: 10.1016/j.cell.2016.12.004
13. [13]
  R. Martin-Perez, M. Niwa, A. Lopez-Rivas, Apoptosis 17 (2012) 349-363. doi: 10.1007/s10495-011-0673-2
14. [14]
  R. Iurlaro, C. Munoz-Pinedo, FEBS J. 283 (2016) 2640-2652. doi: 10.1111/febs.13598
15. [15]
  C. Munoz-Pinedo, A. Lopez-Rivas, Cell Death Differ. 25 (2018) 226. doi: 10.1038/cdd.2017.155
16. [16]
  F. Dufour, T. Rattier, A.A. Constantinescu, et al., Oncotarget 8 (2017) 9974-9985. doi: 10.18632/oncotarget.14285
17. [17]
  Z.Q. Deng, L.L. Yu, W.Q. Cao, et al., Chem. Commun. 51 (2015) 2637-2640. doi: 10.1039/C4CC07926D
18. [18]
  H.Q. Lai, X. Zhang, P.J. Feng, et al., Chem. Asian J. 12 (2017) 982-987. doi: 10.1002/asia.201700272
19. [19]
  D.L. Zeng, S.L. Deng, C.C. Sang, et al., Bioconjugate Chem. 29 (2018) 2039-2049. doi: 10.1021/acs.bioconjchem.8b00247
20. [20]
  E.S.J. Arner, Free Radical Biol. Med. 120 (2018) S31.
21. [21]
  J.C. Avery, P.R. Hoffmann, Nutrients 10 (2018) 1203. doi: 10.3390/nu10091203
22. [22]
  Y.L. Ye, F. Fu, X.M. Li, et al., J. Cell. Biochem. 117 (2016) 106-117. doi: 10.1002/jcb.25254
23. [23]
  H.Y. Huang, B.L. Yu, P.Y. Zhang, et al., Angew. Chem. Int. Ed. 54 (2015) 14049-14052. doi: 10.1002/anie.201507800
24. [24]
  Q. Chen, L.Z. Feng, J.J. Liu, et al., Adv. Mater. 28 (2016) 7129-7136. doi: 10.1002/adma.201601902
25. [25]
  N. Yamamoto, A.K. Renfrew, B.J. Kim, et al., J. Med. Chem. 55 (2012) 11013-11021. doi: 10.1021/jm3014713
26. [26]
  W. Tao, X.Y. Ji, X.B. Zhu, et al., Adv. Mater. 30 (2018) e1802061. doi: 10.1002/adma.201802061
27. [27]
  J.J. Chen, Z.D. Luo, Z.N. Zhao, et al., Biomaterials 71 (2015) 168-177. doi: 10.1016/j.biomaterials.2015.08.031
28. [28]
  X. Fu, Y. Yang, X. Li, et al., Nanomedicine 12 (2016) 1627-1639. doi: 10.1016/j.nano.2016.01.012
29. [29]
  W. Cao, W. Zheng, T. Chen, Sci. Rep. 5 (2015) 1-11.
30. [30]
  M.P. Rayman, Lancet 379 (2012) 1256-1268. doi: 10.1016/S0140-6736(11)61452-9
31. [31]
  G.F. Combs, Nutrients 7 (2015) 2209-2236. doi: 10.3390/nu7042209
32. [32]
  H. Liu, H. Xu, K. Huang, Metallomics 9 (2017) 21-37. doi: 10.1039/C6MT00195E
33. [33]
  S.Q. Du, H.M. Liu, K.X. Huang, Biochim. Biophys. Acta:Gen. Subj. 1800 (2010) 511-517. doi: 10.1016/j.bbagen.2010.01.005
34. [34]
  S. Arbogast, A. Ferreiro, Antioxid. Redox Signaling 12 (2010) 893-904. doi: 10.1089/ars.2009.2890
35. [35]
  H. Steinbrenner, B. Speckmann, L.O. Klotz, Arch. Biochem. Biophys. 595 (2016) 113-119. doi: 10.1016/j.abb.2015.06.024
36. [36]
  S. Florian, S. Krehl, M. Loewinger, et al., Free Radical Biol. Med. 49 (2010) 1694-1702. doi: 10.1016/j.freeradbiomed.2010.08.029
37. [37]
  S.J. Han, B.C. Lee, S.H. Yim, et al., PLoS One 9 (2014)e95518. doi: 10.1371/journal.pone.0095518
38. [38]
  C. Hetz, Nat. Rev. Mol. Cell Biol. 13 (2012) 89-102. doi: 10.1038/nrm3270
39. [39]
  H. Pelicano, D. Carney, P. Huang, Drug Resist. Updat. 7 (2004) 97-110. doi: 10.1016/j.drup.2004.01.004
40. [40]
  W. Tao, N. Kong, X. Ji, et al., Chem. Soc. Rev. 48 (2019) 2891-2912. doi: 10.1039/C8CS00823J
41. [41]
  X.Y. Ji, Y. Kang, J. Ouyang, et al., Adv. Sci. 6 (2019) 1901211. doi: 10.1002/advs.201901211
42. [42]
  H.X. Liu, W.Q. Lin, L.Z. He, T.F. Chen, Biomaterials 226 (2020) 119545. doi: 10.1016/j.biomaterials.2019.119545
43. [43]
  Y. Ren, Q.S. Sun, Z.G. Yuan, Y.Y. Jiang, Chin. Chem. Lett. 30 (2019) 1233-1236. doi: 10.1016/j.cclet.2019.03.029
44. [44]
  M.L. Circu, T.Y. Aw, Free Radical Biol. Med. 48 (2010) 749-762. doi: 10.1016/j.freeradbiomed.2009.12.022
45. [45]
  M. Redza-Dutordoir, D.A. Averill-Bates, Biochim. Biophys. Acta:Mol. Cell Res. 1863 (2016) 2977-2992. doi: 10.1016/j.bbamcr.2016.09.012
46. [46]
  L.Z. He, S.B. Ji, H.Q. Lai, T.F. Chen, J. Mater, Chem. B 3 (2015) 8383-8393.
47. [47]
  Y.H. Yang, Q. Xie, Z.N. Zhao, et al., ACS Appl. Mater. Interfaces 9 (2017) 25857-25869. doi: 10.1021/acsami.7b07167
48. [48]
  T. Chen, Y.S. Wong, Int. J. Biochem. Cell Biol. 41 (2009) 666-676. doi: 10.1016/j.biocel.2008.07.014
49. [49]
  B.S. Tan, K.H. Tiong, H.L. Choo, et al., Cell Death Dis. 6 (2015) e1826. doi: 10.1038/cddis.2015.191
50. [50]
  A.N. Blackford, S.P. Jackson, Mol. Cell 66 (2017) 801-817. doi: 10.1016/j.molcel.2017.05.015
51. [51]
  N. Wang, Y.X. Feng, L.L. Zeng, et al., ACS Appl. Mater. Interfaces 7 (2015) 14933-14945. doi: 10.1021/acsami.5b03739
52. [52]
  M. Roman, P. Jitaru, C. Barbante, Metallomics 6 (2014) 25-54. doi: 10.1039/C3MT00185G
53. [53]
  Y. Gao, H.C. Feng, K. Walder, et al., FEBS Lett. 563 (2004) 185-190. doi: 10.1016/S0014-5793(04)00296-0
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