Citation: He Gang, Yan Xu, Miao Zhaohua, Qian Haisheng, Ma Yan, Xu Yan, Gao Li, Lu Yang, Zha Zhengbao. Anti-inflammatory catecholic chitosan hydrogel for rapid surgical trauma healing and subsequent prevention of tumor recurrence[J]. Chinese Chemical Letters, ;2020, 31(7): 1807-1811. doi: 10.1016/j.cclet.2020.02.032 shu

Anti-inflammatory catecholic chitosan hydrogel for rapid surgical trauma healing and subsequent prevention of tumor recurrence

He Gang ^a,1 ,
Yan Xu ^b,1 ,
Miao Zhaohua ^a,1 ,
Qian Haisheng ^c ,
Ma Yan ^a,*, ,
Xu Yan ^a ,
Gao Li ^a ,
Lu Yang ^b,*, ,
Zha Zhengbao ^a,*,

a.
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
b.
School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, China
c.
School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, China

yanma@hfut.edu.cn

yanglu@hfut.edu.cn

zbzha@hfut.edu.cn

Received Date: 11 December 2019
Revised Date: 14 February 2020
Accepted Date: 17 February 2020
Available Online: 18 February 2020

Figures(4)

Although occupying pillar position in clinical cancer treatments, surgery itself and surgical trauma would elicit series of local/systemic inflammation-related responses that resulted in high rate of tumor recurrence. Herein, chitosan with conjugated gallic acid (CSG) molecules were coordinated with Fe³⁺ to form CSG/Fe³⁺ hydrogel for filling the tumor-resected cavity with considerable wet-adhesion ability and anti-inflammatory performance. With the assistance of doxorubicin hydrochloride (DOX·HCl), CSG/Fe³⁺/DOX hydrogel exhibited synergistic photothermal-chemo tumor-inhibited performance under near-infrared (NIR) light irradiation for eradicating residual and/or surgical trauma-recruited cancer cells. Thus, our study attempts to show a paradigm that realizes quick surgical trauma healing, inflammation inhibition and prevention of postsurgical tumor recurrence.
- Surgery,
- Anti-inflammation,
- Bactericidal capacity,
- Trauma healing,
- Tumor recurrence
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沈阳化工大学材料科学与工程学院沈阳 110142