Citation: Pingzhou Wu, Qilong Zhou, Xiao-Yu Liu, Fei Xue, Yong Qin. Synthetic studies towards (-)-deserpidine: Total synthesis of the stereoisomer and derivative of (-)-deserpidine[J]. Chinese Chemical Letters, ;2021, 32(1): 401-404. doi: 10.1016/j.cclet.2020.02.009 shu

Synthetic studies towards (-)-deserpidine: Total synthesis of the stereoisomer and derivative of (-)-deserpidine

Pingzhou Wu ^{a, 1} ,
Qilong Zhou ^{b, 1} ,
Xiao-Yu Liu ^a ,
Fei Xue ^{a, *,} ,
Yong Qin ^{a, *,}

a.
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
b.
School of Pharmaceutical Sciences and the Innovative Drug Research Centre, Chongqing University, Chongqing 401331, China

xuefei@scu.edu.cn

yongqin@scu.edu.cn

Received Date: 26 November 2019
Revised Date: 11 January 2020
Accepted Date: 7 February 2020
Available Online: 8 February 2020

Figures(4)

The asymmetric synthesis of 16, 17, 20-epi-deserpidine and a derivative of (-)-deserpidine has been achieved. Key features in the assembly of the pentacyclic framework include a visible-light photocatalytic intra-/inter-/intramolecular radical cascade reaction to construct the tetracyclic ABCD ring system in one-pot and an intramolecularaldol reaction to forge the cyclohexane E ring.
- Yohimbine alkaloids,
- Deserpidine,
- Photoredox catalytic radical cascade,
- reaction,
- Total synthesis
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