Citation: Meng Zhaoxiang, Mi Fen, Lu Fei, Tan Wei, Liu Xiao-Yu, Qin Yong. Assembly of the 6/3/5/6 tetracyclic core of rearranged-type C₁₉-diterpenoid alkaloids[J]. Chinese Chemical Letters, ;2020, 31(7): 1903-1905. doi: 10.1016/j.cclet.2020.01.043 shu

Assembly of the 6/3/5/6 tetracyclic core of rearranged-type C₁₉-diterpenoid alkaloids

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

xyliu@scu.edu.cn

yongqin@scu.edu.cn

Received Date: 23 December 2019
Revised Date: 8 January 2020
Accepted Date: 19 January 2020
Available Online: 20 January 2020

Figures(4)

A synthetic study toward the structurally complex rearranged-type C₁₉-diterpenoid alkaloids leading to construction of the strained 6/3/5/6 tetracyclic core is presented. The synthesis features an intramolecular Diels-Alder cycloaddition reaction to assemble the highly substituted central cyclopropane motif, which may serve as a key strategy for the total synthesis of relevant natural product molecules.
- Diterpenoid alkaloid,
- Diels-Alder cycloaddition,
- Cyclopropane,
- Natural product,
- Total synthesis
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Assembly of the 6/3/5/6 tetracyclic core of rearranged-type C19-diterpenoid alkaloids

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通讯作者: 陈斌, bchen63@163.com

Assembly of the 6/3/5/6 tetracyclic core of rearranged-type C₁₉-diterpenoid alkaloids