Citation: Hu Qiaoqiao, Bai Lan, Zhu Zejiang, Su Zhengying, Bai Peng, Tang Minghai, Dou Caixia, Yan Junfeng, Tong Rongsheng, Zhang Wuyu, Chen Lijuan, Cai Lulu. β-Elemene-loaded polymeric micelles intensify anti-carcinoma efficacy and alleviate side effects[J]. Chinese Chemical Letters, ;2020, 31(3): 915-918. doi: 10.1016/j.cclet.2020.01.008 shu

β-Elemene-loaded polymeric micelles intensify anti-carcinoma efficacy and alleviate side effects

Hu Qiaoqiao ^a,1 ,
Bai Lan ^a,1 ,
Zhu Zejiang ^b ,
Su Zhengying ^b ,
Bai Peng ^b ,
Tang Minghai ^b ,
Dou Caixia ^b ,
Yan Junfeng ^a ,
Tong Rongsheng ^a ,
Zhang Wuyu ^c ,
Chen Lijuan ^b,*, ,
Cai Lulu ^a,*,

a.
Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China
b.
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China
c.
Department of Chemistry, University of Louisville, Louisville, KY 40292, United States

chenlijuan125@163.com

cailulu@med.uestc.edu.cn

Received Date: 8 November 2019
Revised Date: 3 January 2020
Accepted Date: 3 January 2020
Available Online: 7 January 2020

Figures(5)

β-Elemene is a volatile oil used for the treatment of cancer, but poor solubility, low bioavailability, and various adverse reactions limit its application. For ameliorating risks of the venous toxicity of β-elemene, intravenously injectable micelle of β-elemene was prepared using the thin-film hydration method. The results pointed out the micelles were uniformly spherical with about 20.96 ± 0.1966 nm in average diameter and exhibited high entrapment efficiency (99.02% ± 0.88%). As revealed by drug release studies in vitro, β-elemene micelles had sustained drug release. Compared with free β-elemene, the micelles increased the drug cellular uptake and enhanced the anti-tumor effect in vitro through retarding cell cycle and inducing apoptosis. Meanwhile, the elevated serum stability of β-elemene micelles implied less drug leakage and reduced toxicity. The wound healing and tube formation assay in vitro demonstrated the anti-metastasis and anti-angiogenesis effects of β-elemene micelles. Moreover, the pharmacokinetics study showed the AUC and T_1/2 of β-elemene in micelle group were 1.79 and 1.62 times of that in free β-elemene group, suggesting the circulation time of β-elemene in the blood had been prolonged. In addition, β-elemene micelles showed a favorable antitumor response compared with the β-elemene solution on C26 colon cancer-bearing mice model. Local irritation study investigated in rabbits indicated that the β-elemene micelles strikingly mitigated the irritation to the injection sites compared with free β-elemene. These results proved that the micelle could be a good candidate as an auspicious drug delivery system of β-elemene for the prospective clinical treatment of carcinoma.
- β-Elemene,
- mPEG-PCL micelles,
- Antitumor,
- Colon cancer,
- Irritation
1. [1]
  B. Yu, Y. Zheng, X. Shi, et al., Anticancer Agents Med. Chem. 16(2016) 1315-1324. doi: 10.2174/1871520615666151102093825
2. [2]
  Y. Wang, J. Zhong, J. Bai, et al., Curr. Drug Metab. 19(2018) 739-749. doi: 10.2174/1389200219666180511154722
3. [3]
  Y. Guo, X. Wu, Y. Chen, Bull. Chin. Materia Med. 8(1983) 31.
4. [4]
  B. Zhai, Y. Zeng, Z. Zeng, et al., Int. J. Nanomed. Nanosurg.13(2018) 6279-6296. doi: 10.2147/IJN.S174527
5. [5]
  Z. Jiang, J.A. Jacob, D.S. Loganathachetti, et al., Front. Pharmacol. 8(2017) 105.
6. [6]
  L. Tao, L. Zhou, L. Zheng, et al., Cancer Chemother. Pharmacol. 58(2006) 24-34. doi: 10.1007/s00280-005-0137-x
7. [7]
  X. Li, G. Wang, J. Zhao, et al., Cell. Mol. Life Sci. 62(2005) 894-904. doi: 10.1007/s00018-005-5027-1
8. [8]
  G. Wang, X. Li, F. Huang, et al., Cell. Mol. Life Sci. 62(2005) 881-893. doi: 10.1007/s00018-005-5017-3
9. [9]
  J. Zhang, Y. Mao, L. Hou, et al., Chin. J. Cancer Res. 25(2013) 770-776.
10. [10]
  X. Yu, M. Xu, N. Li, et al., Biochem. Biophys. Res. Commun. 490(2017) 514-520. doi: 10.1016/j.bbrc.2017.06.071
11. [11]
  X. Peng, Y. Zhao, X. Liang, et al., Contemp. Clin. Trials 27(2006) 70-82. doi: 10.1016/j.cct.2005.07.002
12. [12]
  F. Shi, G. Yang, J. Ren, et al., Int. J. Nanomed. Nanosurg. 8(2013) 2533-2541.
13. [13]
  M. Chen, J. Zhang, S. Yu, et al., Evid.-Based Complement Altern. Med. 2012(2012) 259523.
14. [14]
  Y. Sun, G. Liu, Y. Zhang, et al., Bioorg. Med. Chem. 17(2009) 1118-1124. doi: 10.1016/j.bmc.2008.12.040
15. [15]
  B. Wang, X. Peng, S. Rao, et al., Chin. J. Integr. Med. 18(2012) 813-823. doi: 10.1007/s11655-012-1271-9
16. [16]
  T. Xu, Z. Ling, J. Du, Asia-Pacific Traditional Medicine 10(2014) 126-128.
17. [17]
  L. Cai, Z. Gu, J. Zhong, et al., Drug Discov. Today 23(2018) 1126-1138. doi: 10.1016/j.drudis.2018.02.009
18. [18]
  Y. Chen, Q. Wu, L. Song, et al., ACS Appl. Mater. Interfaces 7(2015) 534-542. doi: 10.1021/am5066893
19. [19]
  Q. Wu, S. Deng, L. Li, et al., Nanoscale 5(2013) 12480. doi: 10.1039/c3nr04651f
20. [20]
  Y. Wang, X. Liang, R. Tong, et al., J. Biomed. Nanotechnol. 14(2018) 1695-1704. doi: 10.1166/jbn.2018.2626
21. [21]
  Y. Li, W. Jin, H. Yan, et al., Int. J. Pharm. 454(2013) 472-477. doi: 10.1016/j.ijpharm.2013.06.032
22. [22]
  F. Liu, H. Huang, Y. Gong, et al., Chem. Biol. Interact. 263(2017) 46-54. doi: 10.1016/j.cbi.2016.12.014
23. [23]
  Y. Ji, X. Liu, M. Huang, et al., Biomaterials. 192(2019) 416-428. doi: 10.1016/j.biomaterials.2018.11.027
24. [24]
  W. Sun, T. Jiang, Y. Lu, et al., J. Am. Chem. Soc. 136(2014) 14722-14725. doi: 10.1021/ja5088024
25. [25]
  C. Wang, L. Cheng, Z. Liu, Biomaterials 32(2011) 1110-1120. doi: 10.1016/j.biomaterials.2010.09.069
1. [1]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
2. [2]
  Mengjuan Sun , Muye Zhou , Yifang Xiao , Hailei Tang , Jinhua Chen , Ruitao Zhang , Chunjiayu Li , Qi Ya , Qian Chen , Jiasheng Tu , Qiyue Wang , Chunmeng Sun . Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109110-. doi: 10.1016/j.cclet.2023.109110
3. [3]
  Jing Zhang , Charles Wang , Yaoyao Zhang , Haining Xia , Yujuan Wang , Kun Ma , Junfeng Wang . Application of magnetotactic bacteria as engineering microrobots: Higher delivery efficiency of antitumor medicine. Chinese Chemical Letters, 2024, 35(10): 109420-. doi: 10.1016/j.cclet.2023.109420
4. [4]
  Di ZHANG , Tianxiang XIE , Xu HE , Wanyu WEI , Qi FAN , Jie QIAO , Gang JIN , Ningbo LI . Construction and antitumor activity of pH/GSH dual-responsive magnetic nanodrug. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 786-796. doi: 10.11862/CJIC.20240329
5. [5]
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6. [6]
  Jin Wang , Xiaoyan Pan , Junyu Zhang , Qingqing Zhang , Yanchen Li , Weiwei Guo , Jie Zhang . Active molecule-based theranostic agents for tumor vasculature normalization and antitumor efficacy. Chinese Chemical Letters, 2024, 35(8): 109187-. doi: 10.1016/j.cclet.2023.109187
7. [7]
  Zhaomin Tang , Qian He , Jianren Zhou , Shuang Yan , Li Jiang , Yudong Wang , Chenxing Yao , Huangzhao Wei , Keda Yang , Jiajia Wang . Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109742-. doi: 10.1016/j.cclet.2024.109742
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  Hong-Tao Ji , Yu-Han Lu , Yan-Ting Liu , Yu-Lin Huang , Jiang-Feng Tian , Feng Liu , Yan-Yan Zeng , Hai-Yan Yang , Yong-Hong Zhang , Wei-Min He . Nd@C₃N₄-photoredox/chlorine dual catalyzed synthesis and evaluation of antitumor activities of 4-alkylated sulfonyl ketimines. Chinese Chemical Letters, 2025, 36(2): 110568-. doi: 10.1016/j.cclet.2024.110568
9. [9]
  Junjie Wang , Yan Wang , Zhengdong Li , Changqiang Xie , Musammir Khan , Xingzhou Peng , Fabiao Yu . Triphenylamine-AIEgens photoactive materials for cancer theranostics. Chinese Chemical Letters, 2024, 35(6): 108934-. doi: 10.1016/j.cclet.2023.108934
10. [10]
  Haijing Cui , Weihao Zhu , Chuning Yue , Ming Yang , Wenzhi Ren , Aiguo Wu . Recent progress of ultrasound-responsive titanium dioxide sonosensitizers in cancer treatment. Chinese Chemical Letters, 2024, 35(10): 109727-. doi: 10.1016/j.cclet.2024.109727
11. [11]
  Xiaofang Luo , Ye Wu , Xiaokun Zhang , Min Tang , Feiye Ju , Zuodong Qin , Gregory J Duns , Wei-Dong Zhang , Jiang-Jiang Qin , Xin Luan . Peptide-based strategies for overcoming multidrug-resistance in cancer therapy. Chinese Chemical Letters, 2025, 36(1): 109724-. doi: 10.1016/j.cclet.2024.109724
12. [12]
  Tong Zhang , Chao Sun , Shubin Yang , Zimin Cai , Sifeng Zhu , Wendian Liu , Yun Luan , Cheng Wang . Inhalation of taraxasterol loaded mixed micelles for the treatment of idiopathic pulmonary fibrosis. Chinese Chemical Letters, 2024, 35(8): 109248-. doi: 10.1016/j.cclet.2023.109248
13. [13]
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14. [14]
  Huijiao Fu , Peiqin Liang , Qianwen Chen , Yan Wang , Guang Li , Xuzi Cai , Shengtao Wang , Kun Chen , Shengying Shi , Zhiqiang Yu , Xuefeng Wang . COX-2 blocking therapy in cisplatin chemosensitization of ovarian cancer: An allicin-based nanomedicine approach. Chinese Chemical Letters, 2024, 35(8): 109241-. doi: 10.1016/j.cclet.2023.109241
15. [15]
  Yang Liu , Yan Liu , Kaiyin Yang , Zhiruo Zhang , Wenbo Zhang , Bingyou Yang , Hua Li , Lixia Chen . A selective HK2 degrader suppresses SW480 cancer cell growth by degrading HK2. Chinese Chemical Letters, 2024, 35(8): 109264-. doi: 10.1016/j.cclet.2023.109264
16. [16]
  Xiangqian Cao , Chenkai Yang , Xiaodong Zhu , Mengxin Zhao , Yilin Yan , Zhengnan Huang , Jinming Cai , Jingming Zhuang , Shengzhou Li , Wei Li , Bing Shen . Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM. Chinese Chemical Letters, 2024, 35(8): 109199-. doi: 10.1016/j.cclet.2023.109199
17. [17]
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18. [18]
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19. [19]
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20. [20]
  Jing Chen , Peisi Xie , Pengfei Wu , Yu He , Zian Lin , Zongwei Cai . MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids. Chinese Chemical Letters, 2024, 35(4): 108895-. doi: 10.1016/j.cclet.2023.108895

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