Citation: Huang Cheng-Mi, Li Jian, Wang Shun-Yi, Ji Shun-Jun. TFA promoted multi-component reaction of aryldiazonium with sodium metabisulphite and thiols: Construction of thiosulfonate under transition-metal free conditions[J]. Chinese Chemical Letters, ;2020, 31(7): 1923-1926. doi: 10.1016/j.cclet.2019.12.032 shu

TFA promoted multi-component reaction of aryldiazonium with sodium metabisulphite and thiols: Construction of thiosulfonate under transition-metal free conditions

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China

shunyi@suda.edu.cn

shunjun@suda.edu.cn

chemjsj@suda.edu.cn

Received Date: 17 October 2019
Revised Date: 11 December 2019
Accepted Date: 24 December 2019
Available Online: 24 December 2019

Figures(6)

A TFA promoted multi-component reaction of aryldiazonium with sodium metabisulphite and thiols to construct thiosulfonates under transition-metal free conditions is reported. The thiosulfonates were isolated in good yields with broad tolerance of functional group. Readily available inorganic Na₂S₂O₅ was applied as the sulfur dioxide surrogate. This strategy features easily available substrates, mild reaction conditions and free transition-metal catalyst.
- Metal-free,
- Thiosulfonate,
- Sulfur dioxide,
- Sodium metabisulfite
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