Citation: Zhang Jinjin, Wang Huiqiao, Chen Yaru, Xie Haiquan, Ding Chenghua, Tan Jiajing, Xu Kun. Electrochemical synthesis of selenocyanated imidazo[1, 5-a]quinolines under metal catalyst- and chemical oxidant-free conditions[J]. Chinese Chemical Letters, ;2020, 31(6): 1576-1579. doi: 10.1016/j.cclet.2019.11.037 shu

Electrochemical synthesis of selenocyanated imidazo[1, 5-a]quinolines under metal catalyst- and chemical oxidant-free conditions

Zhang Jinjin ^a ,
Wang Huiqiao ^a,*, ,
Chen Yaru ^a ,
Xie Haiquan ^a ,
Ding Chenghua ^a ,
Tan Jiajing ^c,*, ,
Xu Kun ^a,b,**,

a.
College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China
b.
College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100124, China
c.
Department of Organic Chemistry, Faculty of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China

^**

huiqiaowang@163.com

tanjj@mail.buct.edu.cn

xukun@nynu.edu.cn

Received Date: 28 October 2019
Revised Date: 18 November 2019
Accepted Date: 20 November 2019
Available Online: 21 November 2019

Figures(6)

Reported herein is the first example of electrochemical selenocyanation of imidazo[1, 5-a]quinolines with KSeCN under metal catalyst- and chemical oxidant-free conditions. This sustainable strategy shows a broad scope and great compatibility with functional groups, and affords synthetically and biologically important selenocyanated imidazo[1, 5-a]quinolines in good to excellent yields with cheap graphite and Ni plates as the electrodes. The gram-scale synthesis was also successfully conducted, which might demonstrate the potential value of this electrochemical protocol.
- Electrosynthesis,
- Organic electrochemistry,
- Anodic oxidation,
- Imidazoquinoline,
- Selenocyanation
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