Citation: Liu Min, Li Ling-Jun, Zhang Jun, Xu Hui, Dai Hui-Xiong. Palladium-catalyzed meta-C-H bond iodination of arenes with I₂[J]. Chinese Chemical Letters, ;2020, 31(5): 1301-1304. doi: 10.1016/j.cclet.2019.09.057 shu

Palladium-catalyzed meta-C-H bond iodination of arenes with I₂

Liu Min ^a,c,b ,
Li Ling-Jun ^a,c,b ,
Zhang Jun ^d,b ,
Xu Hui ^a,c,b,*, ,
Dai Hui-Xiong ^a,c,b,*,

a.
Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Shanghai 201203, China
b.
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
c.
University of Chinese Academy of Sciences, Beijing 100049, China
d.
School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China

xuhui2018@simm.ac.cn

hxdai@simm.ac.cn

Received Date: 16 August 2019
Revised Date: 17 September 2019
Accepted Date: 29 September 2019
Available Online: 3 October 2019

Figures(6)

Palladium-catalyzed highly meta-selective C -H iodination of phenylacetic acid, benzylphosphonate and benzylsulfonate scaffolds with molecular I₂ is developed using a pyridine-type template. The practical ester linkages enable the directing template easily installed and readily removed. The substrate scope is broad, and alkyl, methoxyl, trifluomethyl, and halo substituents are compatible with this reaction. Further transformations of ibuprofen iodide intermediates by Pd-catalyzed C -C and C-heteroatom bond formation illustrate the broad utility of this method.
- Palladium catalysis,
- meta-C -H iodination,
- Pyridine-based template,
- Practical ester linkages,
- Molecular I₂
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沈阳化工大学材料科学与工程学院沈阳 110142

Palladium-catalyzed meta-C-H bond iodination of arenes with I2

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Palladium-catalyzed meta-C-H bond iodination of arenes with I₂