Citation: Peng Ke, Lv Fengting, Lu Huan, Wang Jianwu, Zhao Hao, Liu Libing, Wang Shu. Conjugated polymer nanoparticles as fluorescence switch for selective cell imaging[J]. Chinese Chemical Letters, ;2020, 31(3): 755-758. doi: 10.1016/j.cclet.2019.09.019 shu

Conjugated polymer nanoparticles as fluorescence switch for selective cell imaging

Peng Ke ^a,b ,
Lv Fengting ^a,*, ,
Lu Huan ^a ,
Wang Jianwu ^a,b ,
Zhao Hao ^a,b ,
Liu Libing ^a ,
Wang Shu ^a,b

a.
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
b.
College of Chemistry, University of Chinese Academy of Sciences, Beijing 100049, China

lvft@iccas.ac.cn

Received Date: 10 August 2019
Revised Date: 9 September 2019
Accepted Date: 10 September 2019
Available Online: 11 September 2019

Figures(6)

Fluorescence switch plays a vital role in bioelectronics and bioimaging. Herein, we presented a new kind of facile electrostatic complex nanoparticles (ECNs) for fluorescence switching in cells and marking of individual cell. The ECNs were prepared by mixing positively charged poly(6-(2-(thiophen-3-yl)ethoxy) hexyl trimethylammonium bromide) (PT) and negatively charged diarylethene sodium salt (DAECOONa). DAE-COONa is a photoswitchable molecule which can be transformed between the ring-closed form and ring-open form under the irradiation of UV or visible light. The closed-form of DAE-COONa can efficiently quench the fluorescence of PT through intermolecular energy transfer, while the open form of DAE-COONa does not influence the emission of PT. Thus, the fluorescence of ECNs can be modulated by light irradiation, and the ECNs with good fluorescence switching performance have been employed for fluorescence imaging and individual cell lighting up process successfully. We demonstrate that the electrostatic complex strategy provides a facile method to construct fluorescence switch for selective cell marking and imaging applications.
- Electrostatic complex nanoparticles,
- Conjugated polymers,
- Fluorescence switch,
- Cell imaging,
- Selective cell lighting up
1. [1]
  D.C. Worth, M. Parsons, J. Cell Sci. 123(2010) 3629-3638. doi: 10.1242/jcs.064485
2. [2]
  J.T. Groves, R. Parthasarathy, M.B. Forstner, Annu. Rev. Biomed. Eng. 10(2008) 311-338. doi: 10.1146/annurev.bioeng.10.061807.160431
3. [3]
  N.S. White, R.J. Errington, Adv. Drug Deliv. Rev. 57(2005) 17-42. doi: 10.1016/j.addr.2004.08.003
4. [4]
  T.N. Figueira, A.S. Veiga, M. Castanho, J. Mol. Struct. 1077(2014) 114-120. doi: 10.1016/j.molstruc.2014.02.037
5. [5]
  G. Maulucci, A. Maiorana, M. Papi, G. Pani, M. de Spirito, Microsc. Microanal. 20(2014) 1198-1207.
6. [6]
  M. Zhu, L. Zhu, J. Han, et al., J. Am. Chem. Soc. 128(2006) 4303-4309. doi: 10.1021/ja0567642
7. [7]
  D. Hu, Z. Tian, W. Wu, W. Wan, A. Li, J. Am. Chem. Soc.130(2008) 15279-15281. doi: 10.1021/ja805948u
8. [8]
  Z. Tian, A. Li, D.H. Hu, Chem. Commun. 47(2011) 1258-1260. doi: 10.1039/C0CC03217D
9. [9]
  F. Bonardi, G. London, N. Nouwen, B. Feringa, A.J.M. Driessen, Angew. Chem. Int. Ed. 49(2010) 7234-7238. doi: 10.1002/anie.201002243
10. [10]
  Q. Zhang, S.J. Rao, T. Xie, et al., Chem 4(2018) 2670-2684. doi: 10.1016/j.chempr.2018.08.030
11. [11]
  W. SzymaNski, D. Yilmaz, A. Koçer, B.L. Feringa, Acc. Chem. Res. 46(2013) 2910-2923. doi: 10.1021/ar4000357
12. [12]
  L. Ming, L.Y. Gu, Q. Zhang, M.Z. Xue, Y.G. Liu, Chin. Chem. Lett. 24(2013) 1014-1018. doi: 10.1016/j.cclet.2013.07.001
13. [13]
  L.X. Yu, Y. Liu, S.C. Chen, Y. Guan, Y.Z. Wang, Chin. Chem. Lett. 25(2014) 389-396. doi: 10.1016/j.cclet.2013.12.014
14. [14]
  Y. Zhang, K. Zhang, J. Wang, Z. Tian, A. Li, Nanoscale 7(2015) 19342-19357. doi: 10.1039/C5NR05436B
15. [15]
  C. Xiao, W.Y. Zhao, D.Y. Zhou, et al., Chin. Chem. Lett. 26(2015) 817-824. doi: 10.1016/j.cclet.2015.05.013
16. [16]
  J.Q. Zhang, Q.C. Wang, L. Zou, C.Y. Jia, Chin. Chem. Lett. 25(2014) 762-766. doi: 10.1016/j.cclet.2014.01.033
17. [17]
  S. Yang, J. Liu, Z. Cao, et al., Dyes Pigment 148(2018) 341-347. doi: 10.1016/j.dyepig.2017.09.040
18. [18]
  S. Zhu, W. Li, W. Zhu, Prog. Chem. 28(2016) 975-992.
19. [19]
  R.M. Dickson, A.B. Cubitt, R.Y. Tsien, W.E. Moerner, Nature 388(1997) 355-358. doi: 10.1038/41048
20. [20]
  M. Andresen, A.C. Stiel, J. Folling, et al., Nat. Biotechnol. 26(2008) 1035-1040. doi: 10.1038/nbt.1493
21. [21]
  Q. Zhang, D.H. Qu, Q.C. Wang, H. Tian, Angew. Chem. Int. Ed. 54(2015) 15789-15793. doi: 10.1002/anie.201509071
22. [22]
  Z. Tian, W. Wu, W. Wan, A. Li, J. Am. Chem. Soc. 131(2009) 4245-4252. doi: 10.1021/ja805150g
23. [23]
  Y. Zou, T. Yi, S. Xiao, et al., J. Am. Chem. Soc. 130(2008) 15750-15751. doi: 10.1021/ja8043163
24. [24]
  C. Yun, J. You, J. Kim, J. Huh, E. Kim, J. Photoch. Photobiol. C -Photochem. Rev. 10(2009) 111-129. doi: 10.1016/j.jphotochemrev.2009.05.002
25. [25]
  S.E. Irvine, T. Staudt, E. Rittweger, J. Engelhardt, S.W. Hell, Angew. Chem. Int. Ed. 47(2008) 2685-2688. doi: 10.1002/anie.200705111
26. [26]
  F.M. Raymo, M. Tomasulo, Chem. Soc. Rev. 34(2005) 327-336. doi: 10.1039/b400387j
27. [27]
  I. Yildiz, E. Deniz, F.M. Raymo, Chem. Soc. Rev. 38(2009) 1859-1867. doi: 10.1039/b804151m
28. [28]
  G. Gao, Y.W. Jiang, W. Sun, F.G. Wu, Chin. Chem. Lett. 29(2018) 1475-1485. doi: 10.1016/j.cclet.2018.07.004
29. [29]
  Y. Chan, M.E. Gallina, X. Zhang, et al., Anal. Chem. 84(2012) 9431-9438. doi: 10.1021/ac302245t
30. [30]
  T. Nakahama, D. Kitagawa, H. Sotome, et al., J. Phys. Chem. C 121(2017) 6272-6281. doi: 10.1021/acs.jpcc.6b12819
31. [31]
  Y. Zhang, K. Zhang, J. Wang, Z. Tian, A.D. Li, Nanoscale 7(2015) 19342-19357. doi: 10.1039/C5NR05436B
32. [32]
  C.L. Zhu, L.B. Liu, Q. Yang, F.T. Lv, S. Wang, Chem. Rev. 112(2012) 4687-4735. doi: 10.1021/cr200263w
33. [33]
  S. Shen, M. Mamat, S. Zhang, et al., Small 4(2019) 1902118.
34. [34]
  C.T. Kuo, A.M. Thompson, M.E. Gallina, et al., Nat. Commun. 7(2016) 11468. doi: 10.1038/ncomms11468
35. [35]
  H. Chong, C. Nie, C. Zhu, et al., Langmuir 28(2012) 2091-2098. doi: 10.1021/la203832h
36. [36]
  G.M. Yang, L.B. Liu, Q. Yang, F.T. Lv, S. Wang, Adv. Funct. Mater. 22(2012) 736-743. doi: 10.1002/adfm.201101764
37. [37]
  C.F. Xing, Q.L. Xu, H.W. Tang, L.B. Liu, S. Wang, J. Am. Chem. Soc. 131(2009) 13117-13124. doi: 10.1021/ja904492x
1. [1]
  Boran Cheng , Lei Cao , Chen Li , Fang-Yi Huo , Qian-Fang Meng , Ganglin Tong , Xuan Wu , Lin-Lin Bu , Lang Rao , Shubin Wang . Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging. Chinese Chemical Letters, 2024, 35(6): 108969-. doi: 10.1016/j.cclet.2023.108969
2. [2]
  Zhixue Liu , Haiqi Chen , Lijuan Guo , Xinyao Sun , Zhi-Yuan Zhang , Junyi Chen , Ming Dong , Chunju Li . Luminescent terphen[3]arene sulfate-activated FRET assemblies for cell imaging. Chinese Chemical Letters, 2024, 35(9): 109666-. doi: 10.1016/j.cclet.2024.109666
3. [3]
  Qian Ren , Xue Dai , Ran Cen , Yang Luo , Mingyang Li , Ziyun Zhang , Qinghong Bai , Zhu Tao , Xin Xiao . A cucurbit[8]uril-based supramolecular phosphorescent assembly: Cell imaging and sensing of amino acids in aqueous solution. Chinese Chemical Letters, 2024, 35(12): 110022-. doi: 10.1016/j.cclet.2024.110022
4. [4]
  Xu Qu , Pengzhao Wu , Kaixuan Duan , Guangwei Wang , Liang-Liang Gao , Yuan Guo , Jianjian Zhang , Donglei Shi . Self-calibrating probes constructed on a unique dual-emissive fluorescence platform for the precise tracking of cellular senescence. Chinese Chemical Letters, 2024, 35(12): 109681-. doi: 10.1016/j.cclet.2024.109681
5. [5]
  Guoxing Liu , Yixin Li , Changming Tian , Yongmei Xiao , Lijie Liu , Zhanqi Cao , Song Jiang , Xin Zheng , Caoyuan Niu , Yun-Lai Ren , Liangru Yang , Xianfu Zheng , Yong Chen . Highly reversible photomodulated hydrosoluble stiff-stilbene supramolecular luminophor induced by cucurbituril. Chinese Chemical Letters, 2024, 35(8): 109403-. doi: 10.1016/j.cclet.2023.109403
6. [6]
  Shaohua Zhang , Xiaojuan Dai , Wei Hao , Liyao Liu , Yingqiao Ma , Ye Zou , Jia Zhu , Chong-an Di . A first-principles study of the Nernst effect in doped polymer. Chinese Chemical Letters, 2024, 35(12): 109837-. doi: 10.1016/j.cclet.2024.109837
7. [7]
  Jia-Mei Qin , Xue Li , Wei Lang , Fu-Hao Zhang , Qian-Yong Cao . An AIEgen nano-assembly for simultaneous detection of ATP and H₂S. Chinese Chemical Letters, 2024, 35(6): 108925-. doi: 10.1016/j.cclet.2023.108925
8. [8]
  Chuan-Zhi Ni , Ruo-Ming Li , Fang-Qi Zhang , Qu-Ao-Wei Li , Yuan-Yuan Zhu , Jie Zeng , Shuang-Xi Gu . A chiral fluorescent probe for molecular recognition of basic amino acids in solutions and cells. Chinese Chemical Letters, 2024, 35(10): 109862-. doi: 10.1016/j.cclet.2024.109862
9. [9]
  Brandon Bishop , Shaofeng Huang , Hongxuan Chen , Haijia Yu , Hai Long , Jingshi Shen , Wei Zhang . Artificial transmembrane channel constructed from shape-persistent covalent organic molecular cages capable of ion and small molecule transport. Chinese Chemical Letters, 2024, 35(11): 109966-. doi: 10.1016/j.cclet.2024.109966
10. [10]
  Qi Wang , Yicong Gao , Feng Lu , Quli Fan . Preparation and Performance Characterization of the Second Near-Infrared Phototheranostic Probe: A New Design and Teaching Practice of Polymer Chemistry Comprehensive Experiment. University Chemistry, 2024, 39(11): 342-349. doi: 10.12461/PKU.DXHX202404141
11. [11]
  Lixian Fu , Yiyun Tan , Yue Ding , Weixia Qing , Yong Wang . Water–soluble and polarity–sensitive near–infrared fluorescent probe for long–time specific cancer cell membranes imaging and C. Elegans label. Chinese Chemical Letters, 2024, 35(4): 108886-. doi: 10.1016/j.cclet.2023.108886
12. [12]
  Jianqiu Li , Yi Zhang , Songen Liu , Jie Niu , Rong Zhang , Yong Chen , Yu Liu . Cucurbit[8]uril-based non-covalent heterodimer realized NIR cell imaging through topological transformation from nanowire to nanorod. Chinese Chemical Letters, 2024, 35(10): 109645-. doi: 10.1016/j.cclet.2024.109645
13. [13]
  Zhi Li , Shuya Pan , Yuan Tian , Shaowei Liu , Weifeng Wei , Jinlin Wang , Tianfeng Chen , Ling Wang . Selenium nanoparticles enhance the chemotherapeutic efficacy of pemetrexed against non-small cell lung cancer. Chinese Chemical Letters, 2024, 35(12): 110018-. doi: 10.1016/j.cclet.2024.110018
14. [14]
  Yang Liu , Yan Liu , Kaiyin Yang , Zhiruo Zhang , Wenbo Zhang , Bingyou Yang , Hua Li , Lixia Chen . A selective HK2 degrader suppresses SW480 cancer cell growth by degrading HK2. Chinese Chemical Letters, 2024, 35(8): 109264-. doi: 10.1016/j.cclet.2023.109264
15. [15]
  Jisheng Liu , Junli Chen , Xifeng Zhang , Yin Wu , Xin Qi , Jie Wang , Xiang Gao . Red blood cell membrane-coated FLT3 inhibitor nanoparticles to enhance FLT3-ITD acute myeloid leukemia treatment. Chinese Chemical Letters, 2024, 35(9): 109779-. doi: 10.1016/j.cclet.2024.109779
16. [16]
  Yunan Yuan , Zhimin Luo , Jie Chen , Chaoliang He , Kai Hao , Huayu Tian . Constructing thermoresponsive PNIPAM-based microcarriers for cell culture and enzyme-free cell harvesting. Chinese Chemical Letters, 2024, 35(7): 109549-. doi: 10.1016/j.cclet.2024.109549
17. [17]
  Yi Liu , Peng Lei , Yang Feng , Shiwei Fu , Xiaoqing Liu , Siqi Zhang , Bin Tu , Chen Chen , Yifan Li , Lei Wang , Qing-Dao Zeng . Topologically engineering of π-conjugated macrocycles: Tunable emission and photochemical reaction toward multi-cyclic polymers. Chinese Chemical Letters, 2024, 35(10): 109571-. doi: 10.1016/j.cclet.2024.109571
18. [18]
  Gongcheng Ma , Qihang Ding , Yuding Zhang , Yue Wang , Jingjing Xiang , Mingle Li , Qi Zhao , Saipeng Huang , Ping Gong , Jong Seung Kim . Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide. Chinese Chemical Letters, 2024, 35(9): 109293-. doi: 10.1016/j.cclet.2023.109293
19. [19]
  Peng Meng , Qian-Cheng Luo , Aidan Brock , Xiaodong Wang , Mahboobeh Shahbazi , Aaron Micallef , John McMurtrie , Dongchen Qi , Yan-Zhen Zheng , Jingsan Xu . Molar ratio induced crystal transformation from coordination complex to coordination polymers. Chinese Chemical Letters, 2024, 35(4): 108542-. doi: 10.1016/j.cclet.2023.108542
20. [20]
  Weiyu Chen , Zenghui Li , Chenguang Zhao , Lisha Zha , Junfeng Shi , Dan Yuan . Enzyme-modulate conformational changes in amphiphile peptide for selectively cell delivery. Chinese Chemical Letters, 2024, 35(12): 109628-. doi: 10.1016/j.cclet.2024.109628

Get Citation

PDF

XML

Metrics

PDF Downloads(6)
Abstract views(893)
HTML views(35)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142