Citation: Yan Chenxu, Shi Limin, Guo Zhiqian, Zhu Weihong. Molecularly near-infrared fluorescent theranostics for in vivo tracking tumor-specific chemotherapy[J]. Chinese Chemical Letters, ;2019, 30(10): 1849-1855. doi: 10.1016/j.cclet.2019.08.038 shu

Molecularly near-infrared fluorescent theranostics for in vivo tracking tumor-specific chemotherapy

Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Shanghai Key Laboratory of Functional Materials Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China

guozq@ecust.edu.cn

Received Date: 6 August 2019
Revised Date: 22 August 2019
Accepted Date: 22 August 2019
Available Online: 23 October 2019

Figures(11)

Molecularly near-infrared (NIR) theranostics, combining in vivo sensing and tumor-specific therapeutic capability within one molecular system, have received considerable attention in recent years. Compared with the visible fluorescence imaging, NIR imaging (emission wavelength at 650-900 nm) possesses unique advantages including the minimum photodamage to biological samples, deep penetration, and low interference from auto-fluorescence. In over past decades, there has been an explosive development in the design of molecular imaging contrasts and imaging-guided therapeutics. In this review, we have sumarried the strategies of the NIR theranostics for imaging and tumor-specific chemotherapy applications in living systems. It is noted that the molecularly NIR theranostic design strategy could address current challenges of real-time in vivo sense-and-release for the intelligent biosensing and personalized treatment.
- Near-infrared fluorescence,
- Fluorescent probe,
- Theranostic,
- Prodrug,
- Chemotherapy
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沈阳化工大学材料科学与工程学院沈阳 110142