Citation: Lin Binxin, Lu Xinling, Li Nan, Xu Ning, Lin Jin-Ming. Effect of Dai-Bai-Jie on the proliferation and migration of the A549 cells[J]. Chinese Chemical Letters, ;2020, 31(2): 476-478. doi: 10.1016/j.cclet.2019.07.066 shu

Effect of Dai-Bai-Jie on the proliferation and migration of the A549 cells

Lin Binxin ^a ,
Lu Xinling ^a,b ,
Li Nan ^a ,
Xu Ning ^a ,
Lin Jin-Ming ^a,*,

a.
Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Department of Chemistry, Tsinghua University, Beijing 100084, China
b.
Department of Chemistry, School of Science, Tianjin University, Tianjin 300000, China

jmlin@mail.tsinghua.edu.cn

Received Date: 4 May 2019
Revised Date: 27 July 2019
Accepted Date: 31 July 2019
Available Online: 1 August 2019

Figures(5)

Lung cancer is the most malignant tumor disease with the highest diagnosis and mortality rate in China. The development of therapeutic drugs is the current research focus. Dai-Bai-Jie is a traditional medicine of the Dai nationality, which is commonly used in the treatment of decreasing swelling, alleviating pain and detoxification. Most of the current researches focused on the component analysis of Dai-Bai-Jie, but few researches studied on its antitumor and pharmacological effect. In this study, we incubated A549 cells with different concentrations of Dai-Bai-Jie. The cell proliferation experiment showed that the DaiBai-Jie solution inhibited the proliferation of A549 cells and caused cell apoptosis. In this work, we confirmed that Dai-Bai-Jie had an inhibitory effect on the proliferation and migration of non-small cell lung cancer A549, which may be used as a novel candidate of anti-tumor therapy for lung cancer patients.
- "Dai-Bai-Jie",
- Apoptosis,
- Proliferation,
- Migration,
- Antineoplastic agents
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