Citation: Sun Haiyu, Wu Guangmiao, Xie Xingang. Synthetic studies towards daphniyunnine B: Construction of AC bicyclic skeleton with two vicinal all carbon quaternary stereocenters[J]. Chinese Chemical Letters, ;2019, 30(8): 1538-1540. doi: 10.1016/j.cclet.2019.06.049 shu

Synthetic studies towards daphniyunnine B: Construction of AC bicyclic skeleton with two vicinal all carbon quaternary stereocenters

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China

xiexg@lzu.edu.cn

Received Date: 19 June 2019
Revised Date: 26 June 2019
Accepted Date: 26 June 2019
Available Online: 27 August 2019

Figures(4)

The AC bicyclic skeleton of daphniyunnine B with the required 3 stereocenters (C4, C5 and C8) was accomplished in a concise route which featured two Claisen-type rearrangement reactions to construct the required vicinal all carbon quaternary stereocenters (C5 and C8) and an intramolecular iodocyclization reaction to assemble the cis-confused bicyclic lactam.
- Daphniyunnine B,
- Vicinal quaternary stereocenters,
- Claisen rearrangement,
- Intramolecular iodo-amidation reaction
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