Citation: Hu Guodong, Jia Huiyi, Zhao Lanning, Cho Dong-Hyung, Fang Jianguo. Small molecule fluorescent probes of protein vicinal dithiols[J]. Chinese Chemical Letters, ;2019, 30(10): 1704-1716. doi: 10.1016/j.cclet.2019.06.039 shu

Small molecule fluorescent probes of protein vicinal dithiols

a.
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
b.
School of Life Sciences, Kyungpook National University, Daegu 41566, Republic of Korea

Corresponding author: Fang Jianguo, fangjg@lzu.edu.cn
Received Date: 23 April 2019
Revised Date: 18 June 2019
Accepted Date: 19 June 2019
Available Online: 20 October 2019

Figures(13)

The vicinal dithiol motif is widely present in proteins, and is critical for proteins' structures and functions. In recent years, a variety of fluorescent probes with high specificity and outstanding optical properties for sensing protein vicinal dithiols have been developed. In this review, we summarized the fluorescent probes of protein vicinal dithiols in literature. These probes are classified into four types based on their acceptor sites, i.e., biarsenical probes, monoarsenical probes, dimaleimide probes and diacrylate probes. Through analyzing the properties of different probes, we expect that this review would help readers further understand the structural factors of these probes and provide the design strategy for novel fluorescent probes with improved properties.
- Fluorescent probe,
- Protein vicinal dithiols,
- Arsenical probe,
- Thiol redox,
- Reaction-based probe
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沈阳化工大学材料科学与工程学院沈阳 110142