Citation: Zhang Xiaoyuan, Liu Wei, Wang Haixia, Zhao Xinne, Zhang Zhenfang, Nienhaus Ulrich Gerd, Shang Li, Su Zhiqiang. Self-assembled thermosensitive luminescent nanoparticles with peptide-Au conjugates for cellular imaging and drug delivery[J]. Chinese Chemical Letters, ;2020, 31(3): 859-864. doi: 10.1016/j.cclet.2019.06.032 shu

Self-assembled thermosensitive luminescent nanoparticles with peptide-Au conjugates for cellular imaging and drug delivery

Zhang Xiaoyuan ^a,b,1 ,
Liu Wei ^a,1 ,
Wang Haixia ^c,d ,
Zhao Xinne ^a ,
Zhang Zhenfang ^a ,
Nienhaus Ulrich Gerd ^c,d,e,f ,
Shang Li ^g,*, ,
Su Zhiqiang ^a,*,

a.
State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, Beijing 100029, China
b.
Faculty of Physics and Astronomy, Friedrich Schiller University Jena, Jena 07743, Germany
c.
Institute of Applied Physics, Karlsruhe Institute of Technology(KIT), Karlsruhe 76128, Germany
d.
Institute of Nanotechnology, Karlsruhe Institute of Technology(KIT), Eggenstein-Leopoldshafen 76344, Germany
e.
Institute of Toxicology and Genetics, Karlsruhe Institute of Technology(KIT), Eggenstein-Leopoldshafen 76344, Germany
f.
Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States
g.
State Key Laboratory of Solidification Processing, Center for Nano Energy Materials, School of Materials Science and Engineering, Northwestern Polytechnical University, Shaanxi Joint Laboratory of Graphene(NPU), Xi'an 710072, China

li.shang@nwpu.edu.cn

suzq@mail.buct.edu.cn

Received Date: 29 April 2019
Revised Date: 11 June 2019
Accepted Date: 18 June 2019
Available Online: 19 June 2019

Figures(4)

A facile and efficient strategy has been developed to fabricate a multifunctional, theranostic anticancer drug delivery platform featuring active targeting, controlled drug release and fluorescence imaging for real-time control of delivery. To this end, thermosensitive poly(N-isopropyl acrylamide) (PNIPAM) nanospheres are decorated with peptide-Au cluster conjugates as a smart nanomedicine platform. A sophisticated trifunctional peptide is designed to release the anticancer drug doxorubicin (DOX), target cells and reduce Au³⁺ ions to form luminescent Au clusters. Importantly, the peptide-Au cluster moieties are attached to the PNIPAM nanospheres via amide bonds rather than noncovalent interactions, significantly improving their stability in biological medium and drug release efficiency. The in vitro experiments showed that DOX was released in an efficient and controlled manner under physiological conditions.
- Peptide-Au bioconjugates,
- PNIPAM nanoparticles,
- Fluorescence,
- Drug delivery,
- Cell imaging
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