Citation: Tu Le, Xu Yuling, Ouyang Qingying, Li Xiangyang, Sun Yao. Recent advances on small-molecule fluorophores with emission beyond 1000 nm for better molecular imaging in vivo[J]. Chinese Chemical Letters, ;2019, 30(10): 1731-1737. doi: 10.1016/j.cclet.2019.05.022 shu

Recent advances on small-molecule fluorophores with emission beyond 1000 nm for better molecular imaging in vivo

Tu Le ^a,1 ,
Xu Yuling ^b,1 ,
Ouyang Qingying ^b,1 ,
Li Xiangyang ^c,*, ,
Sun Yao ^b,*,

a.
College of Chemistry, China University of Petroleum, Qingdao 266555, China
b.
International Joint Research Center for Intelligent Biosensor Technology and Health, Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China
c.
State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China

xyli1@gzu.edu.cn

sunyaogbasp@mail.ccnu.edu.cn

Received Date: 7 April 2019
Revised Date: 26 April 2019
Accepted Date: 9 May 2019
Available Online: 14 October 2019

Figures(5)

In the second near-infrared channel (NIR-Ⅱ, 1000-1700 nm), organic and inorganic fluorophores are designed with superior chemical/optical properties to provide real-time information with deeper penetration depth and higher resolution owing to the innate lower light scattering and absorption of the NIR-Ⅱ imaging than conventional optical imaging. Among them, the small-molecule based fluorophores have been highlighted due to their desirable biocompatibility and favorable pharmacokinetics. In this review, we introduced the latest research progress of the rational design of small-molecule NIR-Ⅱ fluorophores and their impressively biological applications including the NIR-Ⅱ signal imaging, multimodal imaging and theranostic.
- Small-molecule fluorophores,
- The second near-infrared channel,
- Benzo-bisthiadiazole,
- Biomedical imaging
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