Citation: Hu Jieni, Xu Yue, Zhang Yan. Amphiphilic random polycarbonate self-assemble into GSH/pH dual responsive micelle-like aggregates in water[J]. Chinese Chemical Letters, ;2019, 30(12): 2039-2042. doi: 10.1016/j.cclet.2019.05.017 shu

Amphiphilic random polycarbonate self-assemble into GSH/pH dual responsive micelle-like aggregates in water

Hu Jieni ^a ,
Xu Yue ^a ,
Zhang Yan ^a,b,*,

a.
Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China
b.
Key Laboratory of Smart Drug Delivery(Fudan University), Ministry of Education, Shanghai 201203, China

zhang_yan@ecust.edu.cn

Received Date: 20 March 2019
Revised Date: 30 April 2019
Accepted Date: 7 May 2019
Available Online: 7 December 2019

Figures(4)

Responsive polymers have been playing an increasingly important role in a wide variety of applications, such as biomedical materials and biosensors. Herein, we reported a dual-responsive polycarbonate (poly (MN-co-MSS)) based on the macrocyclic Sulfur/Nitrogen-substituted carbonate monomer (MSS/MN) via an enzyme-catalyzed ring-opening copolymerization and Lipase CA Novozym-435 as catalyst, with the disulfide and tertiary amine groups situated on the backbone. The structure of the random copolymers was confirmed by NMR and FTIR. In addition, size exclusion chromatography (SEC) results indicated that the copolymer had a symmetric peak and a relatively narrow polydispersity. Also, the random copolymers can self-assemble into micelle-like aggregates in water due to the hydrophilicity endowed by the amino groups, and the aggregates exhibited rich pH and GSH responsive behavior, which was verified by zeta masters instrument and dynamic light scattering (DLS). Moreover, transmission electron microscopy (TEM) demonstrated the morphology of the micellar aggregates and the variation subjected to the lower pH and GSH, and the responsive mechanism was elaborated. Therefore, these results highlighted a facile synthesis of the environment-responsive polymers and provided a novel GSH/pH responsive material platform for further application.
- Polycarbonate,
- Dual responsive,
- Micelles,
- Ring-opening polymerization,
- Random copolymers
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沈阳化工大学材料科学与工程学院沈阳 110142