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Citation: Wang Wenhuan, Sang Lin, Kong Weizong, Zhao Yiping, Wei Zhiyong, Li Yang. In-chain functionalization through the combination of ring opening copolymerization and oxime "Click" reaction towards X-ray opaque polylactide copolymers[J]. Chinese Chemical Letters, ;2020, 31(2): 551-553. doi: 10.1016/j.cclet.2019.04.062 shu

In-chain functionalization through the combination of ring opening copolymerization and oxime "Click" reaction towards X-ray opaque polylactide copolymers

a.
State Key Laboratory of Fine Chemicals, Liaoning Key Laboratory of Polymer Science and Engineering, Department of Polymer Science and Engineering, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China
b.
School of Automotive Engineering, Dalian University of Technology, Dalian 116024, China
c.
Department of Gastroenterology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China
d.
Department of Radiology, Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China

^*

zywei@dlut.edu.cn

Received Date: 14 March 2019
Revised Date: 17 April 2019
Accepted Date: 22 April 2019
Available Online: 22 April 2019

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X-ray imaging functionalization of biodegradable polyesters is a great demand and challenge in biomedical applications. In this work, a strategy of in-chain functionalization through the combination of ring opening copolymerization and oxime "Click" postfunctionalization was developed towards X-ray opaque polylactide copolymers. A functionalized cyclic carbonate was first synthesized and used as comonomer of polylactide copolymers, which were subjected to postfunctionalization of oxime "Click" reaction towards iodinated polylactide copolymers. The chemical structure and physical properties of the target products were traced and confirmed. In vitro cytotoxicity evaluation with 3T3-Swiss albino by Alamar blue demonstrated a low cytotoxicity. The X-ray radiopacity was analyzed by Micro-CT and quantified by Hounsfield Units value, which could be tailorable by the feedstock. It is a promising X-ray visible implantable biomaterial in biomedical applications.
- Polylactide,
- X-ray radiopacity,
- Iodinated polymer,
- Oxime "Click" reaction,
- In-chain functionalization
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1.
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