Citation: Wang Shuiliang, Fu Zhengjiang, Huang Zhicong, Jiang Yongqing, Guo Shengmei, Cai Hu. Dichloromethane as a methylene synthon for regioselective linkage of diverse carboxylic acids: Direct access to methylene diesters under metal-free conditions[J]. Chinese Chemical Letters, ;2019, 30(6): 1173-1177. doi: 10.1016/j.cclet.2019.04.053 shu

Dichloromethane as a methylene synthon for regioselective linkage of diverse carboxylic acids: Direct access to methylene diesters under metal-free conditions

a.
College of Chemistry, Nanchang University, Nanchang 330031, China
b.
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, CAS, Fuzhou 350002, China

^**

fuzhengjiang@ncu.edu.cn

caihu@ncu.edu.cn

Received Date: 31 December 2018
Revised Date: 16 April 2019
Accepted Date: 18 April 2019
Available Online: 19 June 2019

Figures(2)

A metal-free cross coupling between common CH₂Cl₂ and carboxylic acids has been achieved with K₂CO₃ as the sole additive. This simple protocol is a convenient and cost-effective route to synthesize methylene diesters from a wide scope of carboxylic acids substrates with good functional group tolerance. Several gram-scale reactions have been performed to evaluate the effectiveness and practicality of this protocol.
- Carboxylic acids,
- Dichloromethane,
- Methylene synthon,
- Methylene diesters,
- Metal-free conditions
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沈阳化工大学材料科学与工程学院沈阳 110142