Citation: Liu Lin, Yin Liying, Bian Hang, Zhang Ning. Polymeric nanoparticles of poly(2-oxazoline), tannic acid and doxorubicin for controlled release and cancer treatment[J]. Chinese Chemical Letters, ;2020, 31(2): 501-504. doi: 10.1016/j.cclet.2019.04.041 shu

Polymeric nanoparticles of poly(2-oxazoline), tannic acid and doxorubicin for controlled release and cancer treatment

Liu Lin ^a,1 ,
Yin Liying ^a,1 ,
Bian Hang ^b,*, ,
Zhang Ning ^a,*,

a.
Department of Chemistry, Northeast Normal University, Changchun 130024, China
b.
School of Material Science and Engineering, Jilin Jianzhu University, Changchun 130118, China

bhspring@gmail.com

zhangn380@nenu.edu.cn

Received Date: 19 March 2019
Revised Date: 13 April 2019
Accepted Date: 16 April 2019
Available Online: 17 April 2019

Figures(6)

A straightforward coassembly strategy was developed for the preparation of polymeric nanoparticles driving by the intermolecular hydrogen bond between neutral poly(2-methyl-2-oxaozline) (PMeOx), tannic acid (TA) and doxorubicin hydrochloride (Dox). The occurrence of the hydrogen-bonding amongst the different functionalities within the formed nanoparticles was verified by infrared (IR) spectroscopy. Scanning electron microscopy (SEM), dynamic light scattering (DLS), UV-vis absorption and photoluminescent measurements indicated the rapid formation of uniform and water dispersible/stable nanoparticles. The relative poor stability of PMeOx-TA-Dox in fetal bovine serum (FBS) solution enabled the rapid separation of Dox and PMeOx-TA, facilitating the release of Dox and its entrance into cellular nuclei as revealed by confocal laser scanning microscopy (CLSM). The presented strategy may provide an efficient alternative for the construction of multifunctional nanomedicines.
- Polymeric nanoparticle,
- Poly(2-oxazoline),
- Drug delivery,
- Self-assembly,
- Doxorubicin
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