Citation: Li Li, Chen Yisha, Chen Weijie, Tan Ying, Chen Haiyan, Yin Jun. Photodynamic therapy based on organic small molecular fluorescent dyes[J]. Chinese Chemical Letters, ;2019, 30(10): 1689-1703. doi: 10.1016/j.cclet.2019.04.017 shu

Photodynamic therapy based on organic small molecular fluorescent dyes

Li Li ^a ,
Chen Yisha ^a ,
Chen Weijie ^b ,
Tan Ying ^c ,
Chen Haiyan ^a,**, ,
Yin Jun ^b,c,*,

a.
Department of Biomedical Engineering, School of Engineering, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
b.
Key Laboratory of Pesticide and Chemical Biology, Ministry of Education; Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis; International Joint Research Center for Intelligent BiosensingTechnology and Health; College of Chemistry, Central China Normal University, Wuhan 430079, China
c.
State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China

^**

1020092093@cpu.edu.cn

yinj@mail.ccnu.edu.cn

Received Date: 16 February 2019
Revised Date: 8 April 2019
Accepted Date: 8 April 2019
Available Online: 9 October 2019

Figures(9)

Photodynamic therapy (PDT) has shown promise as an effective treatment modality for cancer and other localized diseases due to its noninvasive properties and spatiotemporal selectivity. Near-infrared (NIR) fluorescent dyes based on organic small molecules are characterized with low cytotoxicity, good biocompatibility and excellent phototoxicity, which are widely used in PDT. In this review, we attempt to summarize the development of imaging-induced PDT based on organic small molecules and classify it according to the structures of dyes including cyanines, 4, 4-difluoro-4-bora-3a, 4a-diaza-s-indacene (BODIPY) analogues, phthalocyanine and other agents such as rhodamine analogues.
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