Citation: Cui Jingjing, Yao Yuhua, Chen Cong, Huang Rui, Zhang Weibing, Qian Junhong. Mitochondria-targeted ratiometric fluorescent probes for micropolarity and microviscosity and their applications[J]. Chinese Chemical Letters, ;2019, 30(5): 1071-1074. doi: 10.1016/j.cclet.2018.12.031 shu

Mitochondria-targeted ratiometric fluorescent probes for micropolarity and microviscosity and their applications

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China

weibingzhang@ecust.edu.cn

junhongqian@ecust.edu.cn

Received Date: 31 October 2018
Revised Date: 26 December 2018
Accepted Date: 28 December 2018
Available Online: 30 May 2018

Figures(6)

Two fluorescent "off-on" probes YYH1 and YYH2 were used for the detection of mitochondrial polarity and viscosity. Both probes have two emission bands: The peak of shorter wavelength was sensitive to the polarity, while that in longer wavelength region was sensitive to the viscosity, which enables us to detect medium polarity and viscosity simultaneously. The lg(I_short/I_long) of YYH1 exhibited linear relationship to the solvent polarity, while that of YYH2 was closely related to the solvent viscosity. Furthermore, both probes showed potential in bioimaging mitochondrial polarity or viscosity in living cells.
- Fluorescent probe,
- Mitochondria,
- Microviscosity,
- Micropolarity
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