Citation: Wu Jing, Qu Ying, Shi Kun, Chu Bingyang, Jia Yanpeng, Xiao Xue, He Qianjun, Qian Zhiyong. Camptothecin@HMSNs/thermosensitive hydrogel composite for applications in preventing local breast cancer recurrence[J]. Chinese Chemical Letters, ;2018, 29(12): 1819-1823. doi: 10.1016/j.cclet.2018.10.004 shu

Camptothecin@HMSNs/thermosensitive hydrogel composite for applications in preventing local breast cancer recurrence

Wu Jing ^a,1 ,
Qu Ying ^a,1 ,
Shi Kun ^a ,
Chu Bingyang ^a ,
Jia Yanpeng ^a ,
Xiao Xue ^b,c,** ,
He Qianjun ^d ,
Qian Zhiyong ^a,*

a.
Department of Hematology and Research Laboratory of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China
b.
Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
c.
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu 610041, China
d.
National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen 518060, China

19811454@qq.com

anderson-qian@163.com

zhiyongqian@scu.edu.cn

Received Date: 23 July 2018
Revised Date: 25 September 2018
Accepted Date: 26 September 2018
Available Online: 10 December 2018

Figures(4)

Camptothecin has a strong tumor killing ability for a variety of tumor cells with its special anti-cancer mechanism including the breast cancer. However, because of its infinite hydrophobic property, its clinical application has been greatly limited. Early prevention of locoregional recurrence for the breast cancer is critical for patients who have undergone breast-conserving therapy. In the study, CPT was used for the inhibition of the recurrence after the operation. The hollow mesoporous silica nanoparticles were used as the carrier to improve the hydrophilic property and increase its bioavailability with the high loading capacity. The ability of the cellular uptake and antitumor activity was increased. Hydrogel was the ideal carrier for local therapy, so the CPT@HMSNs were loaded into the PLEL thermosensitive hydrogel to be injected into the tumor sites after the tumor was resected. The recurrence was reduced in the group of CPT-HMSNs-PLEL and the side effect of CPT was decreased. They exhibit distinguished potential as drug carrier for local delivery.
- Camptothecin,
- Hollow mesoporous silica nanoparticles,
- Breast cancer recurrence,
- Thermosensitive hydrogel,
- Local delivery
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