Citation: Gao Qin, Xie Wensheng, Zhao Lingyun, Wang Yu, Zhang Wei, Cai Qiang. Synthesis of hierarchical sieve-like mesoporous silica nanoparticle aggregates via centrifugal method for drug delivery system[J]. Chinese Chemical Letters, ;2018, 29(12): 1804-1810. doi: 10.1016/j.cclet.2018.09.006 shu

Synthesis of hierarchical sieve-like mesoporous silica nanoparticle aggregates via centrifugal method for drug delivery system

Gao Qin ^a,b,1 ,
Xie Wensheng ^a,b,1 ,
Zhao Lingyun ^a,b ,
Wang Yu ^a,b ,
Zhang Wei ^c,* ,
Cai Qiang ^a,b,**

a.
School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China
b.
State Key Laboratory of New Ceramics and Fine Processing, Advanced Materials of Ministry of Education of China, Tsinghua University, Beijing 100084, China
c.
National Center for NanoScience and Technology, Beijing 100190, China

zhangw@nanoctr.cn

caiqiang@mail.tsinghua.edu.cn

Received Date: 10 April 2018
Revised Date: 25 June 2018
Accepted Date: 26 June 2018
Available Online: 8 December 2018

Figures(7)

A facile approach towards the synthesis of a novel hierarchical sieve-like structure of mesoporous silica nanoparticle aggregates (hsMSNA) is reported using a centrifugal method at room temperature, based on the Kelvin-Helmholtz instability and soft-template method. The developed approach is simple and can potentially be applied for scaled-up preparation. Importantly, scanning electron microscopy, transmission electron microscopy, small-angle X-ray diffraction, and nitrogen adsorption-desorption experiments characterize the mesoporous silica as hsMSNA consisting of 40-100 nm mesoporous silica nanoparticles piled at 1-2 μm cylindrical pores in sieve-like tissues. Further, various pore sizes and sieve-, mesh-, and vesicular-like structures can be obtained by adjusting the reaction conditions. The BrunauerEmmett-Teller specific surface area is as large as 500 m²/g with a 47 cm³/g pore volume, facilitating easy drug loading and delivery. Cytotoxicity assays show that the samples are not cytotoxic under a high concentration of 200 μg/mL. Finally, the high drug encapsulation efficiency and sustained release behaviors indicats the considerable potential of the hsMSNA as a drug delivery system in the field of nanomedicine.
- Mesoporous silica,
- Hierarchical structure,
- Interface growth,
- Centrifugal method,
- Drug delivery system
1. [1]
  C.T. Kresge, M.E. Leonowicz, W.J. Roth, et al., Nature 359 (1992) 710-712. doi: 10.1038/359710a0
2. [2]
  S.F. Badylak, R.M. Nerem, Proc. Acad. Sci. India Sect. B 107 (2010) 3285-3286.
3. [3]
  B.T. Holland, C.F. Blandfor, T. Do, A. Stein, Chem. Mater. 11 (1999) 795-805. doi: 10.1021/cm980666g
4. [4]
  M. Grün, I. Lauer, K.K. Unger, Adv. Mater. 9 (1997) 254-257. doi: 10.1002/adma.19970090317
5. [5]
  Q. Huo, J. Feng, F. Schüth, G.D. Stucky, Chem. Mater. 9 (1997) 14-17. doi: 10.1021/cm960464p
6. [6]
  T. Asefa, Z. Tao, Chem. Res. Toxicol. 25 (2012) 2265-2284. doi: 10.1021/tx300166u
7. [7]
  L. Qi, J. Ma, H. Cheng, Z. Zhao, Chem. Mater. 10 (1998) 1623-1626. doi: 10.1021/cm970811a
8. [8]
  M. Vallet-Regi, A. Rámila, R.P. del Real, J. Pérez-Pariente, Chem. Mater. 13 (2001) 308-311. doi: 10.1021/cm0011559
9. [9]
  B.G. Trewyn, I.I. Slowing, S. Giri, et al., Acc. Chem. Res. 40 (2007) 846-853. doi: 10.1021/ar600032u
10. [10]
  G.V. Rama Rao, G.P. López, J. Bravo, et al., Adv. Mater. 14 (2002) 1301-1304. doi: 10.1002/1521-4095(20020916)14:18<1301::AID-ADMA1301>3.0.CO;2-T
11. [11]
  X.J. Wu, D. Xu, Adv. Mater. 22 (2010) 1516-1520. doi: 10.1002/adma.200903879
12. [12]
  J. Liu, S.Z. Qiao, S.B. Hartono, G.Q.M. Lu, Angew. Chem. 122 (2010) 5101-5105. doi: 10.1002/ange.v122:29
13. [13]
  J. Li, J. Liu, D. Wang, et al., Langmuir 26 (2010) 12267-12272. doi: 10.1021/la101225j
14. [14]
  Y.J. Wong, L. Zhu, W.S. Teo, et al., J. Am. Chem. Soc. 133 (2011) 11422-11425. doi: 10.1021/ja203316q
15. [15]
  Q. Yu, P. Wang, S. Hu, et al., Langmuir 27 (2011) 7185-7191. doi: 10.1021/la200719g
16. [16]
  L. Tan, D. Chen, H. Liu, F. Tang, Adv. Mater. 22 (2010) 4885-4889. doi: 10.1002/adma.201002277
17. [17]
  H. Liu, D. Chen, L. Li, et al., Angew. Chem. Int. Ed. 50 (2011) 891-895. doi: 10.1002/anie.201002820
18. [18]
  L. Li, F. Tang, H. Liu, et al., ACS Nano 5 (2011) 679. doi: 10.1021/nn103380r
19. [19]
  T. Suteewong, H. Sai, R. Hovden, et al., Science 340 (2013) 337-341. doi: 10.1126/science.1231391
20. [20]
  F. Tang, L. Li, D. Chen, Adv. Mater. 24 (2012) 1504-1534. doi: 10.1002/adma.201104763
21. [21]
  W. Feng, L. Chen, X. Zhou, et al., J. Control. Release 213 (2015) e108-e109.
22. [22]
  J. O'Connor, Y. Lang, J. Chao, et al., Small 10 (2014) 469-473. doi: 10.1002/smll.v10.3
23. [23]
  S. Davidson, D.A. Lamprou, A.J. Urquhart, et al., ACS Biomater. Sci. Eng. 2 (2016) 1493-1503. doi: 10.1021/acsbiomaterials.6b00224
24. [24]
  D.I. Meiron, G.R. Baker, S.A. Orszag, J. Fluid Mech. 114 (1982) 283-298. doi: 10.1017/S0022112082000159
25. [25]
  O. Trofymluk, A.A. Levchenko, A. Navrotsky, Microporous Mesoporous Mater. 149 (2012) 119-125. doi: 10.1016/j.micromeso.2011.08.022
26. [26]
  X. Yan, Z. Lei, J. Colloid Interface Sci. 362 (2011) 253-260. doi: 10.1016/j.jcis.2011.06.062
27. [27]
  D. Zhao, J. Sun, Q. Li, G.D. Stucky, Chem. Mater. 12 (2000) 275-279. doi: 10.1021/cm9911363
28. [28]
  N.A. Seaton, Chem. Eng. Sci. 46 (1991) 1895-1909. doi: 10.1016/0009-2509(91)80151-N
29. [29]
  M. Kruk, M. Jaroniec, A. Sayari, Adsorption 6 (2000) 47-51. doi: 10.1023/A:1008995015347
30. [30]
  X. Wu, Z. Han, R.M. Schur, Z.R. Lu, ACS Biomater. Sci. Eng. 2 (2016) 501-507. doi: 10.1021/acsbiomaterials.5b00398
31. [31]
  H.P. Jarvie, H. Al-Obaidi, S.M. King, et al., Environ. Sci. Tech. 43 (2009) 8622-8628. doi: 10.1021/es901399q
32. [32]
  Z.M. Cui, Z. Chen, C.Y. Cao, et al., Chem. Commun. 49 (2013) 2332-2334. doi: 10.1039/c3cc38649j
33. [33]
  P. Yang, S. Gai, J. Lin, Chem. Soc. Rev. 41 (2012) 3679-3698. doi: 10.1039/c2cs15308d
34. [34]
  Y. Song, Y. Li, Q. Xu, Z. Liu, Int. J. Nanomed. 12 (2016) 87-110. doi: 10.2147/IJN
35. [35]
  J.L. Vivero-Escoto, I.I. Slowing, B.G. Trewyn, V.S.Y. Lin, Small 6 (2010) 1952-1967. doi: 10.1002/smll.200901789
36. [36]
  W. Xie, Z. Guo, F. Gao, et al., Theranostics 8 (2018) 3284-3307. doi: 10.7150/thno.25220
37. [37]
  B. Cheng, H. He, T. Huang, et al., J. Biomed. Nanotechnol. 12 (2016) 435-449. doi: 10.1166/jbn.2016.2195
38. [38]
  J. Peng, T. Qi, J. Liao, et al., Theranostics 4 (2014) 678-692. doi: 10.7150/thno.7869
39. [39]
  M.Y. Kim, J. Kim, ACS Biomater. Sci. Eng. 3 (2017) 572-578. doi: 10.1021/acsbiomaterials.6b00716
40. [40]
  K.M. Rao, S. Parambadath, A. Kumar, et al., ACS Biomater. Sci. Eng. 4 (2018) 175-183. doi: 10.1021/acsbiomaterials.7b00558
41. [41]
  Q. Gao, W. Xie, Y. Wang, et al., RSC Adv. 8 (2018) 4321-4328. doi: 10.1039/C7RA12446E
42. [42]
  Q. Yang, J. Peng, Y. Xiao, et al., ACS Appl. Mater. Interfaces 10 (2018) 150-164. doi: 10.1021/acsami.7b14705
1. [1]
  Jie Ma , Jianxiang Wang , Jianhua Yuan , Xiao Liu , Yun Yang , Fei Yu . The regulating strategy of hierarchical structure and acidity in zeolites and application of gas adsorption: A review. Chinese Chemical Letters, 2024, 35(11): 109693-. doi: 10.1016/j.cclet.2024.109693
2. [2]
  Wantong Zhang , Zixing Xu , Guofei Dai , Zhijian Li , Chunhui Deng . Removal of Microcystin-LR in lake water sample by hydrophilic mesoporous silica composites under high-throughput MALDI-TOF MS detection platform. Chinese Chemical Letters, 2024, 35(5): 109135-. doi: 10.1016/j.cclet.2023.109135
3. [3]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
4. [4]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
5. [5]
  Shuheng Zhang , Yuanyuan Zhang , Wanyu Wang , Yuzhu Hu , Xinchuan Chen , Bilan Wang , Xiang Gao . A combination strategy of DOX and VEGFR-2 targeted inhibitor based on nanomicelle for enhancing lymphoma therapy. Chinese Chemical Letters, 2024, 35(12): 109658-. doi: 10.1016/j.cclet.2024.109658
6. [6]
  Yanfei Liu , Yaqin Hu , Yifu Tan , Qiwen Chen , Zhenbao Liu . Tumor acidic microenvironment activatable DNA nanostructure for precise cancer cell targeting and inhibition. Chinese Chemical Letters, 2025, 36(1): 110289-. doi: 10.1016/j.cclet.2024.110289
7. [7]
  Xingqun Pu , Rongrong Liu , Yuting Xie , Chenjing Yang , Jingyi Chen , Baoling Guo , Chun-Xia Zhao , Peng Zhao , Jian Ruan , Fangfu Ye , David A Weitz , Dong Chen . One-step preparation of biocompatible amphiphilic dimer nanoparticles with tunable particle morphology and surface property for interface stabilization and drug delivery. Chinese Chemical Letters, 2025, 36(3): 109820-. doi: 10.1016/j.cclet.2024.109820
8. [8]
  Linjie Ju , Zhongxi Huang , Qian Shen , Chan Fu , Shuanghe Li , Wenjie Duan , Chenfeng Xu , Weizhen An , Zhiqiang Zhai , Jifu Wei , Changmin Yu , Guoren Zhou . Glutathione depletion based Pt(Ⅳ) hybrid mesoporous organosilica delivery system to conquer cisplatin chemoresistance: A “one stone three birds” strategy. Chinese Chemical Letters, 2024, 35(10): 109450-. doi: 10.1016/j.cclet.2023.109450
9. [9]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
10. [10]
  Zhaomin Tang , Qian He , Jianren Zhou , Shuang Yan , Li Jiang , Yudong Wang , Chenxing Yao , Huangzhao Wei , Keda Yang , Jiajia Wang . Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109742-. doi: 10.1016/j.cclet.2024.109742
11. [11]
  Jichun Li , Zhengren Wang , Yu Deng , Hongxiu Yu , Yonghui Deng , Xiaowei Cheng , Kaiping Yuan . Construction of mesoporous silica-implanted tungsten oxides for selective acetone gas sensing. Chinese Chemical Letters, 2024, 35(11): 110111-. doi: 10.1016/j.cclet.2024.110111
12. [12]
  Jiaxu Wang , Jinxie Zhang , Xiuping Wang , Jingying Wang , Lina Chen , Jiahui Cao , Wei Cao , Siyu Liang , Ping Luan , Ke Zheng , Xiao-Kun Ouyang , Li Gao , Xiaowen Ou , Fan Zhang , Meitong Ou , Lin Mei . CaCO₃-coated hollow mesoporous silica nanoparticles for pH-responsive fungicides release. Chinese Chemical Letters, 2024, 35(12): 109697-. doi: 10.1016/j.cclet.2024.109697
13. [13]
  Guizhi Zhu , Junrui Tan , Longfei Tan , Qiong Wu , Xiangling Ren , Changhui Fu , Zhihui Chen , Xianwei Meng . Growth of CeCo-MOF in dendritic mesoporous organosilica as highly efficient antioxidant for enhanced thermal stability of silicone rubber. Chinese Chemical Letters, 2025, 36(1): 109669-. doi: 10.1016/j.cclet.2024.109669
14. [14]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
15. [15]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
16. [16]
  Changyuan Bao , Yunpeng Jiang , Haoyin Zhong , Huaizheng Ren , Junhui Wang , Binbin Liu , Qi Zhao , Fan Jin , Yan Meng Chong , Jianguo Sun , Fei Wang , Bo Wang , Ximeng Liu , Dianlong Wang , John Wang . Synergizing 3D-printed structure and sodiophilic interface enables highly efficient sodium metal anodes. Chinese Chemical Letters, 2024, 35(11): 109353-. doi: 10.1016/j.cclet.2023.109353
17. [17]
  Zheng Zhang , Lei Shi , Bin Wang , Jingyuan Qu , Xiaoling Wang , Tao Wang , Qitao Jiang , Wuhong Xue , Xiaohong Xu . Epitaxial growth of full-vdW α-In₂Se₃/MoS₂ heterostructures for all-in-one sensing and memory-computing artificial visual system. Chinese Chemical Letters, 2025, 36(3): 109687-. doi: 10.1016/j.cclet.2024.109687
18. [18]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
19. [19]
  Yi Cao , Xiaojiao Ge , Yuanyuan Wei , Lulu He , Aiguo Wu , Juan Li . Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition. Chinese Chemical Letters, 2024, 35(4): 108672-. doi: 10.1016/j.cclet.2023.108672
20. [20]
  Jiechen Liu , Xiaoguang Li , Ruiyang Xia , Yuqi Wang , Fenghe Zhang , Yongzhi Pang , Qing Li . Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109619-. doi: 10.1016/j.cclet.2024.109619

Get Citation

PDF

XML

Metrics

PDF Downloads(2)
Abstract views(1120)
HTML views(165)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142