Citation: Gao Qin, Xie Wensheng, Zhao Lingyun, Wang Yu, Zhang Wei, Cai Qiang. Synthesis of hierarchical sieve-like mesoporous silica nanoparticle aggregates via centrifugal method for drug delivery system[J]. Chinese Chemical Letters, ;2018, 29(12): 1804-1810. doi: 10.1016/j.cclet.2018.09.006 shu

Synthesis of hierarchical sieve-like mesoporous silica nanoparticle aggregates via centrifugal method for drug delivery system

Gao Qin ^a,b,1 ,
Xie Wensheng ^a,b,1 ,
Zhao Lingyun ^a,b ,
Wang Yu ^a,b ,
Zhang Wei ^c,* ,
Cai Qiang ^a,b,**

a.
School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China
b.
State Key Laboratory of New Ceramics and Fine Processing, Advanced Materials of Ministry of Education of China, Tsinghua University, Beijing 100084, China
c.
National Center for NanoScience and Technology, Beijing 100190, China

zhangw@nanoctr.cn

caiqiang@mail.tsinghua.edu.cn

Received Date: 10 April 2018
Revised Date: 25 June 2018
Accepted Date: 26 June 2018
Available Online: 8 December 2018

Figures(7)

A facile approach towards the synthesis of a novel hierarchical sieve-like structure of mesoporous silica nanoparticle aggregates (hsMSNA) is reported using a centrifugal method at room temperature, based on the Kelvin-Helmholtz instability and soft-template method. The developed approach is simple and can potentially be applied for scaled-up preparation. Importantly, scanning electron microscopy, transmission electron microscopy, small-angle X-ray diffraction, and nitrogen adsorption-desorption experiments characterize the mesoporous silica as hsMSNA consisting of 40-100 nm mesoporous silica nanoparticles piled at 1-2 μm cylindrical pores in sieve-like tissues. Further, various pore sizes and sieve-, mesh-, and vesicular-like structures can be obtained by adjusting the reaction conditions. The BrunauerEmmett-Teller specific surface area is as large as 500 m²/g with a 47 cm³/g pore volume, facilitating easy drug loading and delivery. Cytotoxicity assays show that the samples are not cytotoxic under a high concentration of 200 μg/mL. Finally, the high drug encapsulation efficiency and sustained release behaviors indicats the considerable potential of the hsMSNA as a drug delivery system in the field of nanomedicine.
- Mesoporous silica,
- Hierarchical structure,
- Interface growth,
- Centrifugal method,
- Drug delivery system
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